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Endocannabinoidome : the world of endocannabinoids and related mediators /
The Endocannabinoidome: The World of Endocannabinoids and Related Mediators is dedicated to the latest research and studies on endocannabinoids and cannabinoid receptors to illustrate their important role in the discovery of new, endocannabinoid-related, lipid mediators. Written by leading experts a...
| Clasificación: | Libro Electrónico |
|---|---|
| Autores principales: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press, an imprint of Elsevier,
[2015]
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover; Title Page; Copyright Page; Dedications; Table of contents; Contributors; Preface; References; Acknowledgments; Chapter 1
- Non-endocannabinoid N-Acylethanolamines and Monoacylglycerols: Old Molecules New Targets; 1.1
- Introduction; 1.2
- Formation and degradation of N-acylethanolamines; 1.3
- Biological roles and drug targets of non-endocannabinoid N-acylethanolamines; 1.4
- Formation and degradation of non-endocannabinoid 2-monoacylglycerols; 1.5
- Biological roles and drug targets of non-endocannabinoid 2-monoacylglycerols; 1.6
- Conclusion; Acknowledgment; References.
- Chapter 2
- Omega-3 Polyunsaturated N-Acylethanolamines: A Link Between Diet and Cellular BiologyAbbreviations; 2.1
- Introduction; 2.2
- Modulation of the endocannabinoidome by dietary fatty acids
- biochemical aspects; 2.3
- Effects of diet
- animal studies; 2.4
- Effects of diet
- human data; 2.5
- In vitro formation of n-3 fatty acid derived amides; 2.6
- Biological effects of n-3 fatty acid derived NAEs and other amides; 2.6.1
- Receptor Interaction; 2.6.2
- Effects in Inflammation; 2.6.3
- Effects on COX-2.
- 2.6.4
- Potential Roles of DHEA and EPEA as Endogenous Mediators of Inflammation2.6.5
- Effects in Tumor Cell Lines; 2.6.6
- Role in Neuroprotection and Neurogenesis; 2.7
- Conclusions and future perspectives; References; Chapter 3
- N-Acyl Amides: Ubiquitous Endogenous Cannabimimetic Lipids That Are in the Right Place at the Right Time; 3.1
- N-acyl amides: all in the family; 3.1.1
- How do the Broader Family of N-Acyl Amides Relate to Phytocannabinoids?; 3.2
- GPR18; 3.3
- N-acyl amides/endogenous cannabinoids that activate TRP receptors; 3.3.1
- Activators of other TRP channels.
- 3.3.2
- Enzymes of the eCB System: A Common Link Between Cannabimimetic Endogenous Lipids3.3.3
- Effects of N-Acyl Amides on Additional Cannabinoid-Activated Proteins; 3.3.3.1
- CaV3; 3.3.3.2
- VDAC1; 3.4
- N-acyl amide/eCBs with not yet identified phytocannabinoid ligands; 3.5
- Nowhere to go but up; References; Chapter 4
- Oxidative Metabolites of Endocannabinoids Formed by Cyclooxygenase-2; 4.1
- COX-2 metabolism of endocannabinoids; 4.2
- Analysis of ECs and their COX-2 metabolites; 4.2.1
- AEA and AG; 4.2.2
- Lipoaminoacids; 4.2.3
- Prostaglandin Glyceryl Ester (PG-G).
- 4.2.4
- Prostaglandin Ethanolamides (PG-EAs or Prostamides)4.3
- Tools to study PG-G and PG-EA functions; 4.4
- Biological effects of PG-Gs and PG-EAs; 4.5
- Perspective; References; Chapter 5
- N-Acyldopamines and N-Acylserotonins: From Synthetic Pharmacological Tools to Endogenous Multitarget Mediators; 5.1
- Introduction; 5.2
- N-acyldopamines; 5.2.1
- Synthesis, Discovery as Endogenous Mediators and Metabolic Pathways; 5.2.2
- Molecular Targets; 5.2.2.1
- TRPV1- and/or CB1-Mediated Actions; 5.2.2.2
- Non-TRPV1-, non-CB1-Mediated Actions.
- 5.2.3
- N-Acyldopamine Signaling: Conclusions.