Oral delivery of insulin /

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Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Sonia, Thundiparambil Azeez (Autor), Sharma, Chandra P. (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Oxford : Woodhead Publishing, 2014.
Colección:Woodhead Publishing series in biomedicine ; no. 41.
Temas:
Insulin > Therapeutic use > Administration.
Diabetes > Oral therapy.
Oral medication.
Insulin > administration & dosage
Administration, Oral
Drug Delivery Systems
Hypoglycemic Agents
Insuline > Administration.
Hypoglyc�emiants.
M�edicaments > Administration par voie orale.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Oral medication
Diabetes > Oral therapy
Insulin > Therapeutic use > Administration
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Machine generated contents note: 1. Diabetes mellitus
  • an overview
  • 1.1. Diabetes mellitus
  • an introduction
  • 1.2. Glucose homeostasis
  • 1.3. Types of diabetes
  • 1.4. Symptoms of diabetes
  • 1.5. Complications of diabetes
  • 1.6. Diagnosis of diabetes mellitus
  • 1.7. Therapy for diabetes
  • 1.8. Non-insulin treatment options of type 1 diabetes
  • 1.9. Treatment options of type 2 diabetes
  • 1.10. Conclusion
  • 1.11. References
  • 2. Routes of administration of insulin
  • 2.1. Current approach for the delivery of insulin
  • 2.2. Routes of administration of insulin
  • 2.3. Conclusion
  • 2.4. References
  • 3. Oral insulin delivery
  • challenges and strategies
  • 3.1. Oral delivery of insulin
  • 3.2. Barriers to oral delivery of insulin
  • 3.3. Strategies and alternatives to improve oral insulin delivery
  • 3.4. Conclusion
  • 3.5. References
  • 4. Experimental techniques involved in the development of oral Insulin carriers
  • 4.1. Introduction
  • 4.2. Polymeric nanoparticles
  • 4.3. Physicochemical characterization of nanoparticles
  • 4.4. Biological evaluation
  • 4.5. In vitro method for assessing drug permeability
  • 4.6. In vivo study of oral insulin
  • 4.7. Biodistribution studies
  • 4.8. Conclusion
  • 4.9. References
  • 5. Lipids and inorganic nanoparticles in oral insulin delivery
  • 5.1. Lipid-based systems for oral delivery of insulin
  • 5.2. Liposomes
  • 5.3. Solid lipid nanoparticles
  • 5.4. Nanostructured lipid carriers
  • 5.5. Niosomes
  • 5.6. Archaeosomes
  • 5.7. Cubic nanoparticles (cubosomes)
  • 5.8. Aquasomes
  • 5.9. Inorganic nanoparticles as carriers for oral insulin delivery
  • 5.10. Conclusion
  • 5.11. References
  • 6. Polymers in oral insulin delivery
  • 6.1. Introduction
  • 6.2. Characteristics of an ideal oral insulin carrier
  • 6.3. Polymers in oral insulin delivery
  • 6.4. Natural polymers
  • 6.5. Synthetic polymers
  • 6.6. Conclusion
  • 6.7. References
  • 7. Summary and future perspectives for oral insulin delivery
  • 7.1. Introduction
  • 7.2. Technologies developed for clinical applications of oral insulin delivery
  • 7.3. Conclusions and future perspectives
  • 7.4. References.

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