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Micro- and nanoengineering of the cell surface /
Micro- and Nanoengineering of the Cell Surface explores the direct engineering of cell surfaces, enabling materials scientists and chemists to manipulate or augment cell functions and phenotypes. The book is accessible for readers across industry, academia, and in clinical settings in multiple disci...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Kidlington, Oxford :
Academic Press,
[2014]
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| Colección: | Micro & nano technologies.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Micro- and Nanoengineering of the Cell Surface; Copyright Page; Contents; Foreword; List of Contributors; 1 Cell Membrane Biology and Juxtacrine Signal Conversion; 1.1 Introduction; 1.2 Cell membrane biology-early milestones; 1.3 Membrane microdomains; 1.4 Cell membrane emergence; 1.5 Juxtacrine signaling and rewiring cellular networks; 1.6 Protein painting, artificial veto cell engineering; 1.7 Trans signal conversion; 1.8 Redirecting juxtacrine signals; 1.9 Creating auto-signaling loops; 1.10 SCP therapeutic flexibility; 1.11 The cell membrane frontier; References.
- 2 Cell Surface Engineering by Chemical Reaction and Remodeling2.1 Introduction; 2.2 Methods and technology of covalent cell surface reaction; 2.2.1 Direct chemical modification of cell membrane; 2.2.2 Indirect chemical modification of cell membrane; 2.3 Relevance of covalent cell surface modification; 2.4 Future perspectives; 2.5 Conclusions; References; 3 Bioconjugation Reactions in Living Cells: Development, Advances, and Applications of Glycan-Specific Technologies; 3.1 Introduction; 3.2 Bioorthogonal chemical ligation reactions for glycan labeling.
- 3.2.1 Aldehyde- and Ketone-Based Bioorthogonal Reactions3.2.1.1 Aldehyde-Based Reactions; 3.2.1.2 Metabolic Incorporation Expands Bioorthogonal Ligation to Include Ketone-Based Reactions; 3.2.2 Azide- and Alkyne-Based Bioorthogonal Reactions; 3.2.2.1 Classical and Modified Staudinger Ligation Reactions; 3.2.2.2 Click Reactions: the Copper-Catalyzed [3+2] Azide-Alkyne Cycloaddition; 3.2.2.3 Strain-Promoted Azide-Alkyne Cycloaddition Reactions; 3.2.3 Thiol-based Chemistry; 3.2.4 Photoactivated Ligation Reactions; 3.2.4.1 Benzophenones; 3.2.4.2 Arylazides; 3.2.4.3 Diazirines.
- 3.3 Bioorthogonal ligation reactions: exploitation in MOE-based applications3.3.1 MOE Extends Beyond N-Acyl-Modified Sialic Acid; 3.3.2 Imaging of Living Cells; 3.3.3 In vivo Labeling/Imaging; 3.3.4 Tissue Engineering, Stem Cell Research, and Regenerative Medicine; 3.3.5 Cancer Therapy; 3.4 Concluding comments; References; 4 Pushing the Bacterial Envelope: Strategies for Re-Engineering Bacterial Surfaces with Heterologous Proteins and Sugars; 4.1 Bacterial surface display; 4.2 Strategies for re-engineering bacterial surfaces with heterologous proteins; 4.2.1 Gram-Negative Organisms.
- 4.2.2 Gram-Positive Organisms4.2.3 Spores; 4.2.4 Outer Membrane Vesicles and Bacterial Ghosts; 4.3 Applications of bacteria expressing heterologous surface proteins; 4.3.1 Vaccines Against Infectious Disease; 4.3.2 Anticancer Therapeutics; 4.3.3 Vaccines Against Cancer; 4.3.4 Biocatalysis; 4.3.5 Interactions Between Surface Proteins and Solutes; 4.3.5.1 Biosensing: Binding for Purposes of Detection; 4.3.5.2 Biosorption: Binding for Purposes of Purification; 4.3.5.3 Screening: Binding for Purposes of Identification; 4.4 Strategies for re-engineering bacterial surfaces with heterologous sugars.