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Advances in immunology Volume 124 /
Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecul...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Academic Press,
2014.
|
| Colección: | Advances in immunology ;
v. 124. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover ; Advances in Immunology; Copyright; Contents; Contributors; Chapter One: Group 2 Innate Lymphoid Cells in the Lung; 1. Introduction; 2. General Features of ILC2s; 3. Lung ILC2s at Resting Condition; 4. Regulation and Function of Lung ILC2s; 5. Potential Crosstalk Between ILC2s and Other Immune Cells; 6. Roles of ILC2s in Asthma and Allergic Airway Responses; 7. Roles of ILC2s in Allergic Airway Diseases in Humans; 8. Concluding Remarks; References; Chapter Two: The Ubiquitin System in Immune Regulation; 1. Introduction; 1.1. The ubiquitin system; 1.2. Deubiquitination
- 1.1. The problem of immune self-tolerance2. The CD28 Pathway; 2.1. CD28 in the thymus; 2.2. CD28 and Treg homeostasis; 2.3. CD28 signals and T cell activation; 2.4. CD28 and T cell differentiation; 2.5. CD28 and memory responses; 2.6. CD28 and anergy; 2.7. CD28 and metabolism; 3. CD80 and CD86: The Ligands for CD28 and CTLA-4; 4. CTLA-4; 4.1. Cell biology of CTLA-4; 4.2. CTLA-4 function; 4.2.1. A cell-extrinsic function for CTLA-4 in vivo; 4.2.2. CTLA-4 and Treg; 5. Transendocytosis as a Model of CTLA-4 Function; 5.1. CTLA-4-expressing cells can reduce the levels of ligand on APC
- 5.2. Transendocytosis exploits the biophysical ligand-binding characteristics of CTLA-45.3. Transendocytosis explains the requirement for ligand sharing by CD28 and CTLA-4; 5.4. Transendocytosis is a cell-extrinsic, ligand-dependent, CD28-dependent mechanism; 5.5. Transendocytosis exploits the complex trafficking behavior in CTLA-4; 5.6. Suppression by transendocytosis is easily overridden; 6. An Integrated Perspective on CD28 and CTLA-4; References; Chapter Five: How to Trigger a Killer: Modulation of Natural Killer Cell Reactivity on Many Levels; 1. Introduction