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Perspectives in basic and applied toxicology /
Perspectives in Basic and Applied Toxicology features a collection of essays on various aspects of toxicology. It aims to relate fundamental knowledge of toxicology to its application in assessing relevance of that information to the causation of adverse health effects, predicting hazardous situatio...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Wright,
1988.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Perspectives in Basic and Applied Toxicology; Copyright Page; Preface; Contributors; Table of Contents; CHAPTER 1. BIOCHEMICAL METHODS FOR ASSESSMENT OF NEUROTOXICITY; INTRODUCTION; BIOCHEMICAL MARKERS; METABOLIC PROCESSES OF THE NERVOUS SYSTEM; BIOCHEMICAL CORRELATES OF NEUROPATHOLOGICAL CHANGES; SUMMARY; ACKNOWLEDGEMENTS; REFERENCES; CHAPTER 2. CHEMICAL EXCITANTS OF CUTANEOUS PAIN ; INTRODUCTION; CHEMICAL IRRITANTS AND INFLAMMATION; CHEMICAL IRRITANTS AND SOMATOSENSORY RECEPTORS; REFERENCES
- CHAPTER 3. OTOTOXICITY: MORPHOLOGICAL AND FUNCTIONAL CORRELATIONS BETWEEN EXPERIMENTAL AND CLINICAL STUDIESTHE DRUGS INVOLVED; MICROANATOMY OF THE INNER EAR; METHODS OF STUDY; EXPERIMENTAL STUDIES; CLINICAL STUDIES; CONCLUSION; ACKNOWLEDGEMENTS; REFERENCES; CHAPTER 4. XENOBIOTIC-LNDUCED RHABDOMYOLYSIS; INTRODUCTION; GENERAL FEATURES OF RHABDOMYOLYSIS; RHABDOMYOLYSIS ASSOCIATED WITH XENOBIOTICS; THERAPEUTIC SUBSTANCES; COMMERCIAL PRODUCTS; INDUSTRIAL MATERIALS; SUMMARY; REFERENCES; CHAPTER 5. DRUG-INDUCED OESOPHAGITIS; REFERENCES
- CHAPTER 6. REVIEW OF RECENT ADVANCES IN THE DEVELOPMENT AND APPLICATION OF THE MICRONUCLEUS TEST SYSTEMINTRODUCTION; BACKGROUND AND PRINCIPLE OF THE METHOD; FACTORS AFFECTING THE SENSITIVITY OF THE TEST SYSTEM; DETERMINATION OF MICRONUCLEI IN CIRCULATING ERYTHROCYTES; TRANSPLACENTAL MICRONUCLEUS TEST; APPLICATION TO HUMAN MONITORING; APPLICATION OF THE MICRONUCLEUS TEST TO SCREENING POTENTIAL CARCINOGENS; MONITORING CHROMOSOMAL DAMAGE IN GERM CELLS; APPLICATION TO BIOLOGICAL DOSIMETRY; SUMMARY; ACKNOWLEDGEMENTS; REFERENCES; CHAPTER 7. CHEMICAL INDUCTION OF DOMINANT LETHAL MUTATIONS IN MAMMALS
- EXPERIMENTAL METHODSEXPERIMENTAL METHODS; USE OF THE DOMINANT LETHAL ASSAY; MODE OF ACTION; CHEMICAL EXAMPLE; REFERENCES; CHAPTER 8. DEVELOPMENTAL TOXICITY IN TOXICOLOGIC RESEARCH AND TESTING; INTRODUCTION AND BACKGROUND; GOVERNMENTAL TEST RULES AND GUIDELINES; INTERACTIONS AND IMPLICATIONS; SUMMARY AND CONCLUSIONS; ACKNOWLEDGEMENTS; REFERENCES; CHAPTER 9. THE ROLE OF GENETIC DIFFERENCES AS A DETERMINANT IN XENOBIOTIC-INDUCED DEVELOPMENTAL TOXICITY; THE COMPLEXITY OF DEVELOPMENTAL TOXICOLOGY; GENETICS; CONCLUDING REMARKS; REFERENCES; CHAPTER 10. A SURVEY OF IN VITRO TERATOLOGY TESTS
- INTRODUCTIONLIMITATIONS OF SHORT-TERM IN VITRO ASSAYS; ADVANTAGES OF IN VITRO TESTING; MAMMALIAN EMBRYO; INVERTEBRATE EMBRYOS; AQUATIC EMBRYOS; AVIAN EMBRYO; SUMMARY; REFERENCES; CHAPTER 11. CARCINOGENICITY TESTS IN ANIMALS: SOME PITFALLS THAT COULD BE AVOIDED; INTRODUCTION; EVALUATION OF RESULTS; DIET; VIRUSES; GENETIC FACTORS; HORMONES; THE ROLE OF TISSUE DAMAGE AND HYPERPLASIA IN THE PRODUCTION OF TUMOURS; CONCLUSION; REFERENCES; CHAPTER 12. EXPERIMENTAL APPROACHES TO THE DESIGN AND ASSESSMENT OF ANTIDOTAL PROCEDURES; ACUTE TOXICITY OF THE TOXICANT; CHOICE OF ANIMAL MODEL