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Advances in drug research. Volume 22 /

Advances in Drug Research, Volume 22 focuses on the concepts and facts of drug research. This book is divided into four chapters. Chapter 1 discusses the use of atomic properties and atom-centered indices in QSAR models, while Chapter 2 describes the pharmacokinetics of peptides and proteins. The nu...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Testa, Bernard (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: [Place of publication not identified] : Academic Press, 1992.
Colección:Advances in drug research ; vol. 22.
Temas:
Acceso en línea:Texto completo
Texto completo

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245 0 0 |a Advances in drug research.  |n Volume 22 /  |c edited by Bernard Testa. 
264 1 |a [Place of publication not identified] :  |b Academic Press,  |c 1992. 
300 |a 1 online resource (224 pages) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
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490 1 |a Advances in drug research ;  |v Vol 22 
500 |a Includes indexes. 
588 0 |a Print version record. 
505 0 |6 880-01  |a Front Cover; Advances in Drug Research; Copyright Page; Table of Contents; CONTRIBUTORS; PREFACE: All mimsy were the borogoves -- Chapter 1. Atom Description in QSAR Models: Development and Use of an Atom Level Index; 1 Introduction; 2 An Atom Level Description of Structure; 3 Formulation of an Atom-Centred Index; 4 Information from Electrotopological State Values; 5 QSAR Strategy; 6 Applications to Drug QSAR Problems; 7 Discussion; References; Chapter 2. Pharmacokinetics of Peptides and Proteins: Opportunities and Challenges; 1 Introduction. 
505 8 |a 2 Physicochemical Factors and Passive Distribution3 Clearance; 4 Transport of Peptides Across Mucosal Surfaces; 5 Conclusions; References; Chapter 3. Towards Genomic Pharmacology: From Membranal to Nuclear Receptors; 1 Introduction; 2 Regulation of Gene Expression; 3 Nuclear Receptors; 4 Induced Changes in Gene Expression; 5 The Nucleus as a Target for Drug Action; 6 Signal Pathways: From Membrane to Nuclear Receptors; 7 Future Prospects; Acknowledgements; References; Chapter 4. Medicinal Chemistry of Steroids: Recent Developments; 1 Introduction; 2 Steroid Receptors. 
520 |a Advances in Drug Research, Volume 22 focuses on the concepts and facts of drug research. This book is divided into four chapters. Chapter 1 discusses the use of atomic properties and atom-centered indices in QSAR models, while Chapter 2 describes the pharmacokinetics of peptides and proteins. The nuclear receptors, emphasizing the aspects of molecular and genomic pharmacology are elaborated in Chapter 3. The last chapter covers the medicinal chemistry of a vast group of agents acting on nuclear receptors. This publication is valuable to drug researchers and students interested in advances in d. 
504 |a Includes bibliographical references at the end of each chapters and indexes. 
546 |a English. 
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700 1 |a Testa, Bernard,  |e editor. 
776 0 8 |i Print version:  |t Advances in drug research  |z 0120133229  |w (OCoLC)26214172 
830 0 |a Advances in drug research ;  |v vol. 22. 
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880 8 |6 505-01/(S  |a 3 Steroid-Converting Enzymes: The Case of 3-Oxo-Δ5-Steroid Isomerase4 Inhibitors of Steroid-Converting Enzymes; 5 Oestrogen Receptor-Based Imaging Agents; 6 Conclusions and Future Developments; References; SUBJECT INDEX; CUMULATIVE INDEX OF AUTHORS; CUMULATIVE INDEX OF TITLES.