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Drug design. Volume III /
Drug Design, Volume III covers the mode of action of biologically active compounds. The book discusses microbial transformations that have been used in the preparation of drugs or closely related substances; the use of linear free energy parameters and other experimental constants in structure-activ...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Academic Press,
1972.
|
| Colección: | Medicinal chemistry (Academic Press) ;
v. 11. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Drug design. |n Volume III / |c edited by E.J. Ari�ens. |
| 264 | 1 | |a New York : |b Academic Press, |c 1972. | |
| 300 | |a 1 online resource : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
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| 490 | 1 | |a Medicinal chemistry ; |v volume 11 | |
| 504 | |a Includes bibliographical references and indexes. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |6 880-01 |a Front Cover; Drug Design; Copyright Page; Table of Contents; List of Contributors; Preface; Contents of Other Volumes; Chapter 1. Microbial Conversion as a Tool in the Preparationof Drugs; I. Introduction; II. Practical Aspects of Microbial Transformations; III. Some Theoretical Aspects of Microbial Transformations; IV. Conversions by Microorganisms; ACKNOWLEDGMENTS; REFERENCES; Chapter 2. The Use of Linear Free Energy Parameters and Other Experimental Constants in Structure-Activity Studies; I. Introduction; II. Parameters Used in Structure-Activity Studies. | |
| 505 | 8 | |6 880-02 |a Chapter 6. The Design of Local AnestheticsI. Introduction; II. General Considerations on the Development of New Drugs; III. The Classical Procedures for the Development of Local Anesthetics; IV. Rational Methods for the Development of Local Anesthetics; References; Chapter 7. Design of Insect Chemosterilants; I. Introduction; II. Desirable Characteristics of Chemosterilants; III. Methods of Evaluating Chemosterilants; IV. Mechanism of Action; V. Some Unexplored Areas of Research; REFERENCES; Chapter 8. Molecular Approach for Designing Inhibitors to Enzymes Involved in Blood Clotting. | |
| 505 | 8 | |a I. Background InformationII. Thrombin; III. Fibrinoligase; IV. Conclusion; REFERENCES; Author Index; Subject Index. | |
| 520 | |a Drug Design, Volume III covers the mode of action of biologically active compounds. The book discusses microbial transformations that have been used in the preparation of drugs or closely related substances; the use of linear free energy parameters and other experimental constants in structure-activity studies; and the mode of action of anticoagulants structurally and functionally related to vitamin K. The text also describes the design of beta-blocking drugs, biologically active acridines, local anesthetics, and insect chemosterilants. The molecular approach for designing inhibitors to enzym. | ||
| 650 | 0 | |a Pharmacology. | |
| 650 | 0 | |a Pharmaceutical chemistry. | |
| 650 | 0 | |a Drugs. | |
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| 700 | 1 | |a Ari�ens, E. J. |q (Everhardus Jacobus), |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Drug design |z 0120603012 |w (DLC) 72127678 |w (OCoLC)308826 |
| 830 | 0 | |a Medicinal chemistry (Academic Press) ; |v v. 11. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780120603039 |z Texto completo |
| 880 | 8 | |6 505-01/(S |a III. The Multiparameter Approach to Structure-Activity RelationshipsIV. Interpretation of Regression Equations; V. Application of the Hansch Approach; ACKNOWLEDGMENTS; REFERENCES; Chapter 3. Anticoagulants Structurally and Functionally Related to Vitamin K; I. Introduction; II. Mode of Action of Vitamin K; III. Biological Activity of Vitamin K Analogs; IV. The Structure of Compounds with Vitamin K Activity; V. The Structure of Compounds with Anticoagulant Activity; REFERENCES; Chapter 4. Design of β-Blocking Drugs; I. Introduction; II. Characteristics of β-Adrenoceptor Antagonists. | |
| 880 | 8 | |6 505-02/(S |a III. Structure-Activity Relationships in ArylethanolaminesIV. Other Phenylethanolamine Derivatives; V. Structure-Activity Relationships in Aryloxypropanolamines; VI. Structure-Activity Relationships in Selective β-Adrenoceptor Antagonists; VII. Other Properties in Relation to β-Blockade; VIII. Summary; REFERENCES; Chapter 5. The Design of Biologically Active Acridines; I. Introduction: Ionization and Antibacterial Action; II. Binding to Nucleic Acids: Intercalation and Chemotherapy; III. Prevention of Binding to Nucleic Acids : Pharmacodynamics; IV. Conclusion; REFERENCES. | |