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Drug design. Volume II /
Drug Design, Volume II covers the design of bioactive compounds interacting with enzymes and playing a role in enzyme synthesis. The book discusses the modulation of pharmacokinetics by molecular manipulation; the factors in the design of reversible and irreversible enzyme inhibitors; and the design...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Academic Press,
1971.
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| Colección: | Medicinal chemistry (Academic Press) ;
v. 11. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Drug Design; Copyright Page; Table of Contents; List of Contributors; Preface; Introduction; Contents of Other Volumes; Chapter 1. Modulation of Pharmacokinetics by Molecular Manipulation; I. Introduction; II. The Significance of the Chemical Structure of Bioactive Compounds with Regard to the Various Processes Involved in Pharmacokinetics; III. Dissection of the Drug Molecule in Biofunctional Moieties; IV. Modulation of the Distribution of Pharmaca over the Various Compartments in Individual and Environmental Pharmacokinetics by Molecular Manipulation.
- v. Modulation of the Time-Concentration Relationship in the Distribution of Drugs by Molecular ManipulationVI. Summary; REFERENCES; Chapter 2. Factors in the Design of Reversible and Irreversible Enzyme Inhibitors; I. Introduction; II. Mechanism of Action of Selected Drugs; III. Factors Involved in the Reversible Inhibition of Selected Enzymes; IV. Irreversible Inhibition of Selected Enzymes; V. Kinetics of Irreversible Enzyme Inactivation; VI. Tissue-Specific Irreversible Enzyme Inhibitors; VII. Summary; ACKNOWLEDGMENT; REFERENCES.
- Chapter 3. The Design of Organophosphate and Carbamate Inhibitors of CholinesterasesI. Introduction; II. The Structure of the Active Zone of Cholinesterases; III. Design of Organophosphates; IV. Design of Carbamates; V. Future Approaches to Design of Anticholinesterases; REFERENCES; Chapter 4. The Design of Reactivators for Irreversibly Blocked Acetylcholinesterase; Text; REFERENCES; Chapter 5. Inhibition of Protein Biosynthesis: Its Significance in Drug Design; I. Introduction; II. Protein Biosynthesis; III. Inhibitors of Protein Synthesis; IV. Design of Antibacterial Agents.
- v. Design of Amebicidal AgentsVI. Design of Antitumor Agents; VII. Design of Emetic Agents; VIII. Design of Antiviral Agents; IX. Conclusions; ACKNOWLEDGMENT; REFERENCES; Chapter 6. Enzymes and Their Synthesis as a Target for Antibiotic Action; I. Introduction; II. Competitive Inhibitors of Enzymes; III. Irreversible Inhibitors or Enzymes as Antibacterial Agents; IV. Conclusion; REFERENCES; Chapter 7. The Rational Design of Antiviral Agents; I. Introduction; II. Approaches to the Design of Antiviral Agents; III. Conclusions; ACKNOWLEDGMENTS; REFERENCES; Chapter 8. Design of Penicillins.