Cargando…
Drug design. Volume II /
Drug Design, Volume II covers the design of bioactive compounds interacting with enzymes and playing a role in enzyme synthesis. The book discusses the modulation of pharmacokinetics by molecular manipulation; the factors in the design of reversible and irreversible enzyme inhibitors; and the design...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Academic Press,
1971.
|
| Colección: | Medicinal chemistry (Academic Press) ;
v. 11. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
| LEADER | 00000cam a2200000 i 4500 | ||
|---|---|---|---|
| 001 | SCIDIR_ocn884459817 | ||
| 003 | OCoLC | ||
| 005 | 20231120111705.0 | ||
| 006 | m o d | ||
| 007 | cr cnu---unuuu | ||
| 008 | 140723s1971 nyua ob 001 0 eng d | ||
| 040 | |a OPELS |b eng |e rda |e pn |c OPELS |d E7B |d N$T |d YDXCP |d EBLCP |d OCLCQ |d UAB |d OCLCA |d OCLCQ |d OCLCO |d OCLCA |d MERUC |d OCLCO |d STF |d OCLCO |d OCLCQ |d OCLCA |d OCLCQ |d OCLCO |d OCLCQ |d OCLCO |d OCLCQ |d OCL |d OCLCO | ||
| 066 | |c (S | ||
| 019 | |a 896795676 |a 907156209 | ||
| 020 | |a 9781483216041 |q (electronic bk.) | ||
| 020 | |a 1483216047 |q (electronic bk.) | ||
| 020 | |z 9780120603022 | ||
| 035 | |a (OCoLC)884459817 |z (OCoLC)896795676 |z (OCoLC)907156209 | ||
| 050 | 4 | |a RM300 |b .D74 1971eb | |
| 060 | 4 | |a QV 744 A698d | |
| 072 | 7 | |a MED |x 071000 |2 bisacsh | |
| 082 | 0 | 4 | |a 615/.1 |2 22 |
| 245 | 0 | 0 | |a Drug design. |n Volume II / |c edited by E.J. Ari�ens. |
| 264 | 1 | |a New York : |b Academic Press, |c 1971. | |
| 300 | |a 1 online resource : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Medicinal chemistry ; |v volume 11 | |
| 504 | |a Includes bibliographical references and indexes. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |6 880-01 |a Front Cover; Drug Design; Copyright Page; Table of Contents; List of Contributors; Preface; Introduction; Contents of Other Volumes; Chapter 1. Modulation of Pharmacokinetics by Molecular Manipulation; I. Introduction; II. The Significance of the Chemical Structure of Bioactive Compounds with Regard to the Various Processes Involved in Pharmacokinetics; III. Dissection of the Drug Molecule in Biofunctional Moieties; IV. Modulation of the Distribution of Pharmaca over the Various Compartments in Individual and Environmental Pharmacokinetics by Molecular Manipulation. | |
| 505 | 8 | |a v. Modulation of the Time-Concentration Relationship in the Distribution of Drugs by Molecular ManipulationVI. Summary; REFERENCES; Chapter 2. Factors in the Design of Reversible and Irreversible Enzyme Inhibitors; I. Introduction; II. Mechanism of Action of Selected Drugs; III. Factors Involved in the Reversible Inhibition of Selected Enzymes; IV. Irreversible Inhibition of Selected Enzymes; V. Kinetics of Irreversible Enzyme Inactivation; VI. Tissue-Specific Irreversible Enzyme Inhibitors; VII. Summary; ACKNOWLEDGMENT; REFERENCES. | |
| 505 | 8 | |a Chapter 3. The Design of Organophosphate and Carbamate Inhibitors of CholinesterasesI. Introduction; II. The Structure of the Active Zone of Cholinesterases; III. Design of Organophosphates; IV. Design of Carbamates; V. Future Approaches to Design of Anticholinesterases; REFERENCES; Chapter 4. The Design of Reactivators for Irreversibly Blocked Acetylcholinesterase; Text; REFERENCES; Chapter 5. Inhibition of Protein Biosynthesis: Its Significance in Drug Design; I. Introduction; II. Protein Biosynthesis; III. Inhibitors of Protein Synthesis; IV. Design of Antibacterial Agents. | |
| 505 | 8 | |a v. Design of Amebicidal AgentsVI. Design of Antitumor Agents; VII. Design of Emetic Agents; VIII. Design of Antiviral Agents; IX. Conclusions; ACKNOWLEDGMENT; REFERENCES; Chapter 6. Enzymes and Their Synthesis as a Target for Antibiotic Action; I. Introduction; II. Competitive Inhibitors of Enzymes; III. Irreversible Inhibitors or Enzymes as Antibacterial Agents; IV. Conclusion; REFERENCES; Chapter 7. The Rational Design of Antiviral Agents; I. Introduction; II. Approaches to the Design of Antiviral Agents; III. Conclusions; ACKNOWLEDGMENTS; REFERENCES; Chapter 8. Design of Penicillins. | |
| 520 | |a Drug Design, Volume II covers the design of bioactive compounds interacting with enzymes and playing a role in enzyme synthesis. The book discusses the modulation of pharmacokinetics by molecular manipulation; the factors in the design of reversible and irreversible enzyme inhibitors; and the design of organophosphate and carbamate inhibitors of cholinesterases. The text also describes the design of reactivators for irreversibly blocked acetylcholinesterase; drug design based on the inhibition of protein synthesis in the context of susceptible enzymic reactions; as well as the role of enzymes. | ||
| 650 | 0 | |a Pharmacology. | |
| 650 | 0 | |a Pharmaceutical chemistry. | |
| 650 | 0 | |a Drugs. | |
| 650 | 0 | |a Research. | |
| 650 | 2 | |a Chemistry, Pharmaceutical |0 (DNLM)D002626 | |
| 650 | 2 | |a Pharmaceutical Preparations |0 (DNLM)D004364 | |
| 650 | 2 | |a Research |0 (DNLM)D012106 | |
| 650 | 2 | |a Pharmacology |0 (DNLM)D010600 | |
| 650 | 6 | |a Pharmacologie |0 (CaQQLa)201-0007219 |x Collections. | |
| 650 | 6 | |a Chimie pharmaceutique. |0 (CaQQLa)201-0028674 | |
| 650 | 6 | |a Pharmacologie. |0 (CaQQLa)201-0007219 | |
| 650 | 6 | |a M�edicaments. |0 (CaQQLa)201-0002990 | |
| 650 | 6 | |a Recherche. |0 (CaQQLa)201-0029424 | |
| 650 | 7 | |a pharmacology. |2 aat |0 (CStmoGRI)aat300137970 | |
| 650 | 7 | |a research (function) |2 aat |0 (CStmoGRI)aat300054687 | |
| 650 | 7 | |a MEDICAL |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a Research |2 fast |0 (OCoLC)fst01095153 | |
| 650 | 7 | |a Drugs |2 fast |0 (OCoLC)fst00898761 | |
| 650 | 7 | |a Pharmaceutical chemistry |2 fast |0 (OCoLC)fst01060115 | |
| 650 | 7 | |a Pharmacology |2 fast |0 (OCoLC)fst01060259 | |
| 650 | 7 | |a M�edicaments |x Conception. |2 ram | |
| 650 | 7 | |a M�edicaments |x Relations structure-activit�e. |2 ram | |
| 650 | 7 | |a M�edicaments |x Pharmacocin�etique. |2 ram | |
| 700 | 1 | |a Ari�ens, E. J. |q (Everhardus Jacobus), |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Drug design |z 0120603012 |w (DLC) 72127678 |w (OCoLC)308826 |
| 830 | 0 | |a Medicinal chemistry (Academic Press) ; |v v. 11. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780120603022 |z Texto completo |
| 880 | 8 | |6 505-01/(S |a I. IntroductionII. Effect of Penicillins on Bacteria; III. Behavior of Penicillins in Vivo; IV. Derivatives Which Liberate Penicillins in Vivo; V. Concluding Remarks; ACKNOWLEDGMENT; REFERENCES; Chapter 9. The Design of Peptide Hormone Analogs; I. Introduction; II. Structural Aspects of Design; III. Biological Aspects and Practical Aims of Design; IV. Conclusions; ACKNOWLEDGMENTS; REFERENCES; Chapter 10. Recent Advances in the Design of Diuretics; I. Introduction; II. Mono- and Bicyclic Nitrogen Heterocycles; III. Sulfonamides and Disulfonamides; IV. α, β-Unsaturated Ketone Derivatives. | |