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Telomeres in health and disease /
This special volume of Progress in Molecular Biology and Translational Science focuses on telomeres in health and disease. This volume covers a variety of topics with reviews written by experts in the field. Contributions from specialists in telomere diseases Informs and updates on how telomere dysf...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Burlington :
Elsevier Science,
2014.
|
| Colección: | Progress in molecular biology and translation science ;
v. 125. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
MARC
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| 245 | 0 | 0 | |a Telomeres in health and disease / |c edited by Rodrigo T. Calado. |
| 260 | |a Burlington : |b Elsevier Science, |c 2014. | ||
| 300 | |a 1 online resource (205 pages) | ||
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| 490 | 1 | |a Progress in molecular biology and translation science ; |v v. 125 | |
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a Front Cover; Telomeres in Health and Disease; Copyright; Contents; Contributors; Preface; Chapter One: Telomere and Telomerase Biology; 1. Introduction; 2. The General Structure of Telomeric DNA; 2.1. Telomere loops and G-quartets: Specialized structures at the ends of eukaryotic chromosomes; 3. Replication of Telomeres; 3.1. The telomerase RNP complex; 3.1.1. The reverse transcriptase component; 3.1.2. Telomerase accessory factors; 3.1.3. The telomerase RNA component; 3.1.4. How telomeres are replicated by telomerase; 3.1.5. Regulation of telomerase activity in mammals. | |
| 505 | 8 | |a 3.2. Telomere replication in the absence of telomerase4. Telomeric Chromatin: Implications for End Protection, Telomere Replication, and Telomere Length Regulation; 4.1. CST: The major telomere end-binding complex on eukaryotic telomeres; 4.2. Shelterin: A conserved, double-stranded, telomeric protein complex that associates with the telomere end-binding CST ... ; 5. TERRA: The Telomeric RNA Transcript; 6. Consequences of Telomere Deprotection; Acknowledgments; References; Chapter Two: Human Telomeres and Telomere Biology Disorders; 1. Introduction; 2. Telomere Biology in Humans. | |
| 505 | 8 | |a 2.1. Telomeric structure2.2. Telomerase and telomere-associated proteins; 2.3. Alternative lengthening of telomeres; 2.4. Measuring TL; 3. What Is a TBD?; 4. Clinical Features of the TBDs; 4.1. Dyskeratosis congenita; 4.2. Hoyeraal-Hreidarsson syndrome; 4.3. Revesz syndrome; 4.4. Coats plus syndrome/CRMCC; 4.5. Aplastic anemia; 4.6. Pulmonary fibrosis; 4.7. Nonalcoholic/noninfectious liver disease; 4.8. Genetic anticipation; 5. Germ-Line Genetics of TBDs; 6. Diagnosing TBDs; 7. Genetic Counseling Considerations; 8. Clinical Management; 8.1. Bone marrow failure; 8.2. Pulmonary fibrosis. | |
| 505 | 8 | |a 9. Summary and Future DirectionsAcknowledgments; References; Chapter Three: Telomere Biology in Stem Cells and Reprogramming; 1. Introduction; 1.1. A variety of stem cells throughout organismal development; 1.2. Telomeres cap chromosomal ends; 2. Telomere Homeostasis in Stem Cells; 2.1. Telomerase activity in pluripotent stem cells; 2.2. Telomerase activity in adult multipotent cells; 2.2.1. Hematopoietic system; 2.2.2. Hair follicle stem cells; 2.2.3. Intestinal stem cells; 2.2.4. Muscle stem cells; 2.2.5. Neural stem cells; 2.2.6. Spermatogonial stem cells. | |
| 505 | 8 | |a 2.3. Organismal consequences of telomere attrition in stem cells2.4. Noncanonical roles of telomerase in stem cell regulation; 3. Cellular Reprogramming; 3.1. Somatic cell nuclear transfer and cell fusion; 3.1.1. Telomere biology in SCNT; 3.2. Reprogramming through induced pluripotency; 3.2.1. Telomere reprogramming in iPS cells; 3.2.2. Derivation of IPS cells harboring disease-associated telomerase mutations; 4. Conclusions; References; Chapter Four: Telomere Dynamics and Aging. | |
| 500 | |a 1. Introduction: Telomere Structure, Determinants of Telomere Dynamics, Measurement Parameters, and Regulation Mechanisms. | ||
| 520 | |a This special volume of Progress in Molecular Biology and Translational Science focuses on telomeres in health and disease. This volume covers a variety of topics with reviews written by experts in the field. Contributions from specialists in telomere diseases Informs and updates on how telomere dysfunction may cause disease in humans. | ||
| 650 | 0 | |a Telomerase. | |
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| 650 | 7 | |a Telomerase |2 fast |0 (OCoLC)fst01147182 | |
| 700 | 1 | |a Calado, Rodrigo. | |
| 776 | 0 | 8 | |i Print version: |a Calado, Rodrigo. |t Telomeres in Health and Disease. |d Burlington : Elsevier Science, �2014 |z 9780123978981 |
| 830 | 0 | |a Progress in molecular biology and translation science ; |v v. 125. | |
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