Cargando…
Advances in cancer research. Volume one hundred and twenty one /
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego, California :
Academic Press,
2014.
|
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
MARC
| LEADER | 00000cam a2200000 i 4500 | ||
|---|---|---|---|
| 001 | SCIDIR_ocn882252486 | ||
| 003 | OCoLC | ||
| 005 | 20231120111656.0 | ||
| 006 | m o d | ||
| 007 | cr cn||||||||| | ||
| 008 | 140616t20142014caua ob 001 0 eng d | ||
| 040 | |a E7B |b eng |e rda |e pn |c E7B |d OCLCO |d OPELS |d OCLCF |d EBLCP |d OCLCQ |d UAB |d OCLCQ |d D6H |d OTZ |d NLE |d N$T |d UKMGB |d OCLCQ |d VT2 |d OCLCO |d OCLCQ |d OCLCO | ||
| 015 | |a GBB8H4783 |2 bnb | ||
| 016 | 7 | |a 019053486 |2 Uk | |
| 019 | |a 881162177 |a 881318635 | ||
| 020 | |a 9780128003176 |q (electronic bk.) | ||
| 020 | |a 0128003170 |q (electronic bk.) | ||
| 020 | |z 9780128002490 | ||
| 035 | |a (OCoLC)882252486 |z (OCoLC)881162177 |z (OCoLC)881318635 | ||
| 050 | 4 | |a RC267 |b .A383 2014eb | |
| 072 | 7 | |a HEA |x 039000 |2 bisacsh | |
| 072 | 7 | |a MED |x 014000 |2 bisacsh | |
| 072 | 7 | |a MED |x 022000 |2 bisacsh | |
| 072 | 7 | |a MED |x 112000 |2 bisacsh | |
| 072 | 7 | |a MED |x 045000 |2 bisacsh | |
| 072 | 7 | |a MJCL |2 bicssc | |
| 072 | 7 | |a PS |2 bicssc | |
| 082 | 0 | 4 | |a 616.9940072 |2 23 |
| 245 | 0 | 0 | |a Advances in cancer research. |n Volume one hundred and twenty one / |c edited by Kenneth D. Tew, Paul B. Fisher. |
| 264 | 1 | |a San Diego, California : |b Academic Press, |c 2014. | |
| 264 | 4 | |c �2014 | |
| 300 | |a 1 online resource (461 pages) : |b illustrations (some color), graphs | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 504 | |a Includes bibliographical references at the end of each chapters and index. | ||
| 588 | 0 | |a Online resource; title from PDF title page (ebrary, viewed June 15, 2014). | |
| 520 | |a Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. | ||
| 505 | 0 | |a Front Cover; Advances in Cancer Research; Copyright; Contents; Contributors; Chapter One: Glial Progenitors as Targets for Transformation in Glioma; 1. Introduction; 2. Glial Cell Lineages; 3. Glioma Subgroups and Cell of Origin; 4. H3F3A Mutations Drive Gliomagenesis in Separate Brain Regions; 4.1. Regulation of DNA methylation by K27 and G34 H3F3A mutations; 4.2. Chromosome and Myc aberrations in H3F3A mutant glioblastoma; 4.3. Delineating the cell of origin for K27 and G34 H3F3A mutant glioblastoma; 5. Gliomagenesis and Mutations in Isocitrate Dehydrogenase Genes. | |
| 505 | 8 | |a 5.1. Models of IDH-mutant gliomas5.2. Glial progenitor-origin for IDH-mutant gliomas; 6. Proneural-to-Mesenchymal Transition in Glioma; 6.1. Mesenchymal phenotype as a function of glioma subgroup; 6.2. Transcriptional master regulators of PMT in glioma; 6.3. Influence of the tumor microenvironment on the mesenchymal phenotype; 7. Relationship Between GSCs and Glial Progenitors; 7.1. Polycomb gene family; 7.2. NOTCH; 7.3. Sonic hedgehog; 7.4. Wingless; 8. Targeted Therapy in Glioma; 8.1. Epidermal growth factor gene family; 8.2. Targeting the proneural subgroup by PDGFR inhibition. | |
| 505 | 8 | |a 8.3. Targeting the mesenchymal phenotype through c-MET inhibition8.4. Treatment-resistance associated with RTK inhibition; 8.4.1. RTK cooperativity; 8.4.2. Redundant activation of PI3K/mTOR; 8.4.3. Feedback loops; 8.4.4. Activation of alternative survival pathways; 8.5. Therapeutic targeting of IDH-mutant gliomas; 9. Concluding Remarks and Future Perspectives; Acknowledgments; References; Further Reading; Chapter Two: Therapeutic Cancer Vaccines; 1. Introduction; 2. Cancer Vaccine Targets; 3. Spectrum of Current Therapeutic Cancer Vaccine Platforms. | |
| 505 | 8 | |a 3.1. An example of optimizing vaccine potency3.2. Vaccine/vaccine combinations; 4. Animal Models to Evaluate Cancer Vaccines: Pros and Cons; 5. Types of Immunotherapy; 5.1. Vaccine therapy and adoptive T-cell transfer: A study in contrasts; 6. The Importance of Antigen Cascade in Vaccine-Mediated Therapeutic Responses; 7. TRICOM-Based Vaccines: Clinical Studies; 8. Prostate Cancer Clinical Trials; 8.1. PSA-TRICOM (PROSTVAC) studies; 8.2. Vaccines and tumor growth rates; 8.3. A case report: Analysis of a prostate cancer patient over an 18-year period; 9. Vaccine Combination Therapies. | |
| 505 | 8 | |a 10. Combination Therapies-Preclinical Studies10.1. Vaccine and radiation synergy; 10.2. Vaccines in combination with chemotherapy; 10.3. Vaccine in combination with small molecule targeted therapies; 10.4. The effect of nonimmune therapeutic interventions on immune cells; 11. Influence of the Tumor Microenvironment and Immunosuppressive Factors; 12. Vaccine Combination Therapies-Clinical Studies; 13. Biomarkers; 14. Vaccine Targets Involved in Tumor Progression and Drug Resistance; 15. Concluding Remarks; References. | |
| 650 | 0 | |a Cancer |x Research. | |
| 650 | 0 | |a Cancer |x Mortality. | |
| 650 | 6 | |a Cancer |x Recherche. |0 (CaQQLa)201-0004697 | |
| 650 | 6 | |a Cancer |x Mortalit�e. |0 (CaQQLa)201-0061546 | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x General. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Clinical Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Diseases. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Evidence-Based Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Internal Medicine. |2 bisacsh | |
| 650 | 7 | |a Cancer |x Mortality |2 fast |0 (OCoLC)fst00845399 | |
| 650 | 7 | |a Cancer |x Research |2 fast |0 (OCoLC)fst00845497 | |
| 700 | 1 | |a Tew, Kenneth D., |e editor. | |
| 700 | 1 | |a Fisher, Paul B., |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Advances in cancer research. Volume one hundred and twenty one. |d San Diego, California : Academic Press, �2014 |h xii, 426 pages |z 9780128002490 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128002490 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/0065230X/121 |z Texto completo |