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Stereoselective synthesis. Part H /
Studies in Natural Products Chemistry Volume 12: Stereoselective Synthesis (Part H) reviews the stereoselective synthetic and mechanistic chemistry of bicyclomycin. It discusses chemical studies of the taxane diterpenes; the synthetic methodology for 2-amino alcohols of biological interest; and the...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Oxford ; New York :
Elsevier,
1993.
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| Colección: | Studies in natural products chemistry ;
12. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Stereoselective Synthesis (Part H); Copyright Page; FOREWORD; PREFACE; Table of Contents ; CONTRIBUTORS; PART 1: Stereoselective Synthesis; Chapter 1. Synthetic Routes to the Oxahydrindene Subunit of the Avermectin- Milbemycin Family of Antiparasitic Agents: A Review; 1. Introduction: Isolation, Structure Elucidation, Biosynthesis, and Biological Activity of the Avermectins; 2. Synthetic Routes to the Oxahydrindene Subunit of the Avermectins; Acknowledgments.; References; Chapter 2. A New Tandem Process and its Application to the Synthesis of Macrolide Antibiotics
- 1. Introduction2. A new tandem process (Two-stage coupling process); 3. Synthesis of the rifamycin S ansa-chain compound; 4. Synthesis of the rifamycin W ansa-chain compound; 5. Total synthesis of rifamycin W; 6. Total synthesis of erythronolide A; 7. Total synthesis of erythromycin A; 8. Mechanistic considerations about the diastereoselective first step (Stage I) of the new tandem process; References; Chapter 3. Stereoselective Synthetic and Mechanistic Chemistry of Bicyclomycin; INTRODUCTION; ISOLATION, STRUCTURAL ELUCIDATION AND BIOSYNTHESIS; MECHANISM OF ACTION; CONCLUDING REMARKS
- 2. TOTAL SYNTHESIS3. THE DEVELOPMENT OF AN A-RING ANNULATION STRATEGY FOR TAXANE SYNTHESIS; 4. PARTIAL SYNTHESIS OF TAXOL AND ITS STRUCTURE-AOTVITY PROFILE; 5. BIOLOGICALLY ACTIVE TAXOL ANALOGUES WITH DELETED �A-RING SIDECHAIN SUBSTITUENTS AND VARIABLE C-2' CONFIGURATIONS; ACKNOWLEDGMENT.; REFERENCES; Chapter 7. Recent Advances in the synthesis of Tumor-Promoting Diterpenes; 1. INTRODUCTION; 2. INGENANE SYNTHETIC STUDIES; 3. PHORBOL SYNTHETIC STUDIES; REFERENCES; Chapter 8. Hydroxylated Indolizidines and their Synthesis; 1. Introduction; 2. The 1-hydroxyindolizidines (octahydroindolizin-l-ols)
- 3. The 2-hydroxyindoIizidines (octahydroindolizin-2-ols)4. The 5-hydroxy-4-oxyindolizidines; 5. The 6-hydroxyindolizidines (octahydroindo!izin-6-oIs); 6. The 7-hydroxyindoIizidines (octahydroindolizin-7-oIs); 7. Elaeokanine C; 8. The 8-hydroxyindoIizidines (octahydroindolizin-8-oIs); 9. The pumiliotoxins; 10. The allopumiliotoxins; 11. The 8a-hydroxyindoIizidines (octahydroindolizin-8a-oIs); 12. The 1,2-dihydroxyindoIizidines (octahydroindoIizin-l,2-dioIs); 13. Slaframine; 14. Swainsonine; 15. Swainsonine stereomers; 16. Castanospermine; 17. Castanospermine stereomers and analogues