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Stereoselective synthesis. Part H /

Studies in Natural Products Chemistry Volume 12: Stereoselective Synthesis (Part H) reviews the stereoselective synthetic and mechanistic chemistry of bicyclomycin. It discusses chemical studies of the taxane diterpenes; the synthetic methodology for 2-amino alcohols of biological interest; and the...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Rahman, Atta-ur-, 1942-
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam ; Oxford ; New York : Elsevier, 1993.
Colección:Studies in natural products chemistry ; 12.
Temas:
Acceso en línea:Texto completo
Texto completo

MARC

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245 0 0 |a Stereoselective synthesis.  |n Part H /  |c edited by Atta-ur-Rahman. 
264 1 |a Amsterdam ;  |a Oxford ;  |a New York :  |b Elsevier,  |c 1993. 
300 |a 1 online resource (xii, 528 pages) 
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490 1 |a Studies in natural products chemistry ;  |v 12 
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505 0 |a Front Cover; Stereoselective Synthesis (Part H); Copyright Page; FOREWORD; PREFACE; Table of Contents ; CONTRIBUTORS; PART 1: Stereoselective Synthesis; Chapter 1. Synthetic Routes to the Oxahydrindene Subunit of the Avermectin- Milbemycin Family of Antiparasitic Agents: A Review; 1. Introduction: Isolation, Structure Elucidation, Biosynthesis, and Biological Activity of the Avermectins; 2. Synthetic Routes to the Oxahydrindene Subunit of the Avermectins; Acknowledgments.; References; Chapter 2. A New Tandem Process and its Application to the Synthesis of Macrolide Antibiotics 
505 8 |a 1. Introduction2. A new tandem process (Two-stage coupling process); 3. Synthesis of the rifamycin S ansa-chain compound; 4. Synthesis of the rifamycin W ansa-chain compound; 5. Total synthesis of rifamycin W; 6. Total synthesis of erythronolide A; 7. Total synthesis of erythromycin A; 8. Mechanistic considerations about the diastereoselective first step (Stage I) of the new tandem process; References; Chapter 3. Stereoselective Synthetic and Mechanistic Chemistry of Bicyclomycin; INTRODUCTION; ISOLATION, STRUCTURAL ELUCIDATION AND BIOSYNTHESIS; MECHANISM OF ACTION; CONCLUDING REMARKS 
505 8 |a 2. TOTAL SYNTHESIS3. THE DEVELOPMENT OF AN A-RING ANNULATION STRATEGY FOR TAXANE SYNTHESIS; 4. PARTIAL SYNTHESIS OF TAXOL AND ITS STRUCTURE-AOTVITY PROFILE; 5. BIOLOGICALLY ACTIVE TAXOL ANALOGUES WITH DELETED �A-RING SIDECHAIN SUBSTITUENTS AND VARIABLE C-2' CONFIGURATIONS; ACKNOWLEDGMENT.; REFERENCES; Chapter 7. Recent Advances in the synthesis of Tumor-Promoting Diterpenes; 1. INTRODUCTION; 2. INGENANE SYNTHETIC STUDIES; 3. PHORBOL SYNTHETIC STUDIES; REFERENCES; Chapter 8. Hydroxylated Indolizidines and their Synthesis; 1. Introduction; 2. The 1-hydroxyindolizidines (octahydroindolizin-l-ols) 
505 8 |a 3. The 2-hydroxyindoIizidines (octahydroindolizin-2-ols)4. The 5-hydroxy-4-oxyindolizidines; 5. The 6-hydroxyindolizidines (octahydroindo!izin-6-oIs); 6. The 7-hydroxyindoIizidines (octahydroindolizin-7-oIs); 7. Elaeokanine C; 8. The 8-hydroxyindoIizidines (octahydroindolizin-8-oIs); 9. The pumiliotoxins; 10. The allopumiliotoxins; 11. The 8a-hydroxyindoIizidines (octahydroindolizin-8a-oIs); 12. The 1,2-dihydroxyindoIizidines (octahydroindoIizin-l,2-dioIs); 13. Slaframine; 14. Swainsonine; 15. Swainsonine stereomers; 16. Castanospermine; 17. Castanospermine stereomers and analogues 
520 |a Studies in Natural Products Chemistry Volume 12: Stereoselective Synthesis (Part H) reviews the stereoselective synthetic and mechanistic chemistry of bicyclomycin. It discusses chemical studies of the taxane diterpenes; the synthetic methodology for 2-amino alcohols of biological interest; and the synthesis and structure of hydroxylated indolizidines. Some of the topics covered in the book are the synthetic routes to the oxahydrindene subunit of the avermectin-milbemycin family of antiparasitic agents; isolation, structure elucidation, biosynthesis, and biological activity of the avermectins 
650 0 |a Natural products. 
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880 |6 504-01/(S  |a REFERENCES AND FOOTNOTESChapter 4. The Role of Isocyanides in the Synthesis of β-Lactam Antibiotics and Related Compounds; 1. INTRODUCTION; 2. �-LACTAM ANTIBIOTICS; 3. MODIFICATIONS OF β-LACTAM ANTIBIOTICS THROUGH ISOCYANIDE CHEMISTRY; 4. PERSPECTIVES; REFERENCES; Chapter 5. Synthesis of the lβ-Methylcarbapenem Key Intermediates Yoshio Ito and Shiro Terashima; 1. Introduction; 2. Construction of the Carbapenem Framework; 3. Synthesis of Key lβ-Methylcarbapenem Intermediates; References; Chapter 6. Chemical Studies of the Taxane Diterpenes Charles S. Swindell; 1. INTRODUCTION