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Biochemical and molecular aspects of selected cancers /
This two-volume work not only includes much of the newer molecular biology research but also important earlier research in this area essential for the comprehensive understanding of the biochemistry of neoplastic diseases. As such it will provide an invaluable source of information for the young inv...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego ; London :
Academic Press.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Biochemical and Molecular Aspects of Selected Cancers; Copyright Page; Table of Contents; PREFACE; Chapter 1. Chronic Myelogenous Leukemia: A Model for the Genetic and Biochemical Basis of Neoplasia; I. Introduction; II. Clinical Features of Chronic Myelogenous Leukemia; III. The Philadelphia Chromosome; IV. Chronic Myelogenous Leukemia Model Systems; V. Chronic Myelogenous Leukemia Blast Phase: A Model of Tumor Progression ; References; Chapter 2. Structural Basis of Oncogenic Activation of Epidermal Growth Factor Receptor; I. Introduction; II. Domain Structure of ErbB/EGFR
- III. EGFR Signal TransductionIV. Oncogenic Activation of Chicken EGFR and Tissue-Specific Transformation; V. Role of EGFR in Human Oncogenesis; VI. Summary; References; Chapter 3. Colonie Carcinoma: A Common Tumor with Multiple Genomic Abnormalities; I. Introduction; II. Background; III. Molecular Events in Tumor Etiology and Progression; IV. Molecular Alterations in Colorectal Cancer; V. Alterations in Gene Expression; VI. Summary and Speculations; References; Chapter 4. Alterations Associated with Early Neoplasia in the Colon; I. Introduction; II. Biochemical Alterations
- III. Morphological AlterationsIV. Concluding Remarks; References; Chapter 5. Genetic Alterations and Gene Expression in Human Malignant Glioma; I. Introduction; II. Genetic Changes in Glioblastoma Multiforme; III. Expression of Unaltered Genes; IV. Conclusions; References; Chapter 6. Biochemistry of Prostatic Carcinoma; I. Introduction; II. Anatomical and Pathological Context; III. Proliferate Fraction; IV. Whole Nuclear DNA and Cytogenetics; V. Altered Genes and Gene Products; VI. Antigens; VII. Hormones, Enzymes, and Miscellaneous; VIII. Interactions between Epithelium and Mesenchyme
- IX. Models of Prostatic CarcinomaX. Conclusions; References; Chapter 7. Androgen Receptors in Human Prostate Cancer; I. Rationale for Androgen Receptor Studies; II. Ligand-Binding Androgen Receptor Assays in Prostate Cancer; III. Quantitative Androgen Receptor Immunohistochemistry; IV. Image Analysis of Androgen Receptor Immunostaining: Heterogeneity as a Predictor of Response; V. Molecular Analysis of Androgen Receptor Gene Structure and Function in Prostate Cancer; VI. Summary; References; Chapter 8. Biochemistry and Molecular Biology of Skin Tumors; I. Introduction
- II. Mouse Skin Carcinogenesis ModelIII. Human Skin Neoplasia; References; Chapter 9. Alterations in Polyamine Metabolism in Epithelial Tumors of the Skin; I. Introduction; II. Polyamine Metabolism in Mouse Epidermis and Epidermal Tumors; III. Heterogeneity of Ornithine Decarboxylase Expression; IV. Hypotheses and Relevance to Other Systems; References; Chapter 10. Carbohydrate Metabolism and Neoplasia: New Perspectives for Diagnosis and Therapy; I. Significance of Aerobic Glycolysis; II. Role of Phosphometabolite Pools in Cell Proliferation and Tumor Formation