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Presystemic drug elimination /
Butterworths International Medical Reviews, Clinical Pharmacology and Therapeutics 1: Presystemic Drug Elimination explores the principles of presystemic drug metabolism in human based on animal studies. This book is divided into four sections encompassing 10 chapters that specifically describe the...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London ; Boston :
Butterworth Scientific,
1982.
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| Colección: | Butterworths international medical reviews. Clinical pharmacology nd therapeutics ;
1. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Presystemic Drug Elimination; Copyright Page; Preface; List of Contributors; Table of Contents; Section 1: Gastrointestinal tract; Chapter 1. First-pass metabolism within the lumen of the gastrointestinal tract; DRUG METABOLIZING OR INACTIVATING SYSTEMS OCCURRING IN THE GUT LUMEN; METHODS FOR STUDYING THE ROLE OF THE GUT FLORA IN FIRST-PASS METABOLISM; REGIONAL VARIATION IN THE EXTENT OF FIRST-PASS METABOLISM; EXAMPLES OF FIRST-PASS METABOLISM IN THE GUT LUMEN; CONCLUSION; References; Chapter 2. Metabolism of drugs by the gastrointestinal tract; INTRODUCTION.
- INDUCTION OF INTESTINAL DRUG METABOLISMCONCLUSION; References; Chapter 3. In vivo studies of gut wall metabolism; INTRODUCTION; SIGNIFICANCE OF GUT METABOLISM: ROUTE-DEPENDENT METABOLIC PROFILES; METHODS OF ASSESSING GUT METABOLISM IN VIVO; PREABSORPTIVE VERSUS POST ABSORPTIVE GUT WALL DRUG ELIMINATION; IN VIVO METABOLISM OF INDIVIDUAL DRUGS; PHARMACOLOGICAL MODIFICATION OF GUT WALL METABOLISM; Induction; Inhibition; References; Section 2: Liver; Chapter 4. Presystemic drug metabolism in the liver; INTRODUCTION; DETERMINANTS OF HEPATIC DRUG METABOLISM IN VIVO.
- AcknowledgementReferences; Chapter 6. Presystemic hepatic drug elimination in cirrhosis; INTRODUCTION; PHARMACOKINETIC APPROACHES TO EVALUATING THE HEPATIC CIRCULATION; CONCLUSIONS; References; Section 3: Lung; First-pass metabolism by the lung: introduction; STRUCTURE AND FUNCTION OF THE LUNGS; QUANTITATIVE ASPECTS OF FIRST-PASS METABOLISM BY THE LUNGS; References; Chapter 7. The metabolic potential of the lungs; INTRODUCTION; COMPOUNDS METABOLIZED BY THE LUNGS; OXIDATION; REDUCTION; CONJUGATION; HYDROLYSIS; FACTORS WHICH INFLUENCE THE METABOLIC POTENTIAL OF THE LUNGS; CONCLUSION; References.
- Chapter 8. First-pass metabolism of endogenous and exogenous substrates by lungINTRODUCTION; PHARMACOKINETIC PROPERTIES OF NORMAL LUNG; FACTORS AFFECTING THE PHARMACOKINETIC FUNCTION OF LUNG; FATE OF EXOGENOUS SUBSTRATES; CONCLUSION; Acknowledgements; References; Chapter 9. Presystemic drug metabolism of exogenous compounds by the lung; METHODS OF STUDYING PRESYSTEMIC METABOLISM IN THE LUNG; ENTRY OF DRUGS VIA THE CIRCULATION; DRUGS REACHING THE LUNGS VIA THE AIRWAYS; PULMONARY METABOLISM AND TOXICITY; PULMONARY METABOLISM AND CARCINOGENICITY; CONCLUSION; References; Section 4: Epilogue.