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Presystemic drug elimination /
Butterworths International Medical Reviews, Clinical Pharmacology and Therapeutics 1: Presystemic Drug Elimination explores the principles of presystemic drug metabolism in human based on animal studies. This book is divided into four sections encompassing 10 chapters that specifically describe the...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London ; Boston :
Butterworth Scientific,
1982.
|
| Colección: | Butterworths international medical reviews. Clinical pharmacology nd therapeutics ;
1. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 050 | 4 | |a RM301.55 | |
| 060 | 4 | |a W1 |b BU98N v.1 1982 | |
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| 245 | 0 | 0 | |a Presystemic drug elimination / |c edited by Charles F. George and David G. Shand ; guest editor, Andrew G. Renwick. |
| 264 | 1 | |a London ; |a Boston : |b Butterworth Scientific, |c 1982. | |
| 300 | |a 1 online resource (213 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Butterworths international medical reviews. Clinical pharmacology nd therapeutics, |x 0260-0099 ; |v 1 | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a Front Cover; Presystemic Drug Elimination; Copyright Page; Preface; List of Contributors; Table of Contents; Section 1: Gastrointestinal tract; Chapter 1. First-pass metabolism within the lumen of the gastrointestinal tract; DRUG METABOLIZING OR INACTIVATING SYSTEMS OCCURRING IN THE GUT LUMEN; METHODS FOR STUDYING THE ROLE OF THE GUT FLORA IN FIRST-PASS METABOLISM; REGIONAL VARIATION IN THE EXTENT OF FIRST-PASS METABOLISM; EXAMPLES OF FIRST-PASS METABOLISM IN THE GUT LUMEN; CONCLUSION; References; Chapter 2. Metabolism of drugs by the gastrointestinal tract; INTRODUCTION. | |
| 505 | 8 | |a INDUCTION OF INTESTINAL DRUG METABOLISMCONCLUSION; References; Chapter 3. In vivo studies of gut wall metabolism; INTRODUCTION; SIGNIFICANCE OF GUT METABOLISM: ROUTE-DEPENDENT METABOLIC PROFILES; METHODS OF ASSESSING GUT METABOLISM IN VIVO; PREABSORPTIVE VERSUS POST ABSORPTIVE GUT WALL DRUG ELIMINATION; IN VIVO METABOLISM OF INDIVIDUAL DRUGS; PHARMACOLOGICAL MODIFICATION OF GUT WALL METABOLISM; Induction; Inhibition; References; Section 2: Liver; Chapter 4. Presystemic drug metabolism in the liver; INTRODUCTION; DETERMINANTS OF HEPATIC DRUG METABOLISM IN VIVO. | |
| 505 | 8 | |6 880-01 |a AcknowledgementReferences; Chapter 6. Presystemic hepatic drug elimination in cirrhosis; INTRODUCTION; PHARMACOKINETIC APPROACHES TO EVALUATING THE HEPATIC CIRCULATION; CONCLUSIONS; References; Section 3: Lung; First-pass metabolism by the lung: introduction; STRUCTURE AND FUNCTION OF THE LUNGS; QUANTITATIVE ASPECTS OF FIRST-PASS METABOLISM BY THE LUNGS; References; Chapter 7. The metabolic potential of the lungs; INTRODUCTION; COMPOUNDS METABOLIZED BY THE LUNGS; OXIDATION; REDUCTION; CONJUGATION; HYDROLYSIS; FACTORS WHICH INFLUENCE THE METABOLIC POTENTIAL OF THE LUNGS; CONCLUSION; References. | |
| 505 | 8 | |a Chapter 8. First-pass metabolism of endogenous and exogenous substrates by lungINTRODUCTION; PHARMACOKINETIC PROPERTIES OF NORMAL LUNG; FACTORS AFFECTING THE PHARMACOKINETIC FUNCTION OF LUNG; FATE OF EXOGENOUS SUBSTRATES; CONCLUSION; Acknowledgements; References; Chapter 9. Presystemic drug metabolism of exogenous compounds by the lung; METHODS OF STUDYING PRESYSTEMIC METABOLISM IN THE LUNG; ENTRY OF DRUGS VIA THE CIRCULATION; DRUGS REACHING THE LUNGS VIA THE AIRWAYS; PULMONARY METABOLISM AND TOXICITY; PULMONARY METABOLISM AND CARCINOGENICITY; CONCLUSION; References; Section 4: Epilogue. | |
| 520 | |a Butterworths International Medical Reviews, Clinical Pharmacology and Therapeutics 1: Presystemic Drug Elimination explores the principles of presystemic drug metabolism in human based on animal studies. This book is divided into four sections encompassing 10 chapters that specifically describe the extent of metabolism occurring in the gastrointestinal tract, liver, and lung. Section 1 focuses on presystemic elimination by the gastrointestinal tract. This section discusses the enzymatic biotransformation in the gastrointestinal mucosa and the ability of the microflora to metabolize drugs. Sec. | ||
| 650 | 0 | |a Drugs |x Metabolism. | |
| 650 | 2 | |a Digestive System |x metabolism |0 (DNLM)D004064Q000378 | |
| 650 | 2 | |a Liver |x metabolism |0 (DNLM)D008099Q000378 | |
| 650 | 2 | |a Lung |x metabolism |0 (DNLM)D008168Q000378 | |
| 650 | 2 | |a Pharmaceutical Preparations |x metabolism |0 (DNLM)D004364Q000378 | |
| 650 | 6 | |a M�edicaments |x M�etabolisme. |0 (CaQQLa)201-0046488 | |
| 650 | 7 | |a MEDICAL |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a Drugs |x Metabolism |2 fast |0 (OCoLC)fst00898845 | |
| 650 | 7 | |a DROGAS (METABOLISMO) |2 larpcal | |
| 650 | 7 | |a TERAP�EUTICA. |2 larpcal | |
| 700 | 1 | |a George, Charles F. | |
| 700 | 1 | |a Shand, David G. | |
| 700 | 1 | |a Renwick, Andrew G. | |
| 730 | 0 | |a Drug elimination. | |
| 776 | 0 | 8 | |i Print version: |t Presystemic drug elimination |z 0407023224 |w (DLC) 82197147 |w (OCoLC)8672464 |
| 830 | 0 | |a Butterworths international medical reviews. |p Clinical pharmacology nd therapeutics ; |v 1. |x 0260-0099 | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780407023222 |z Texto completo |
| 880 | 8 | |6 505-01/(S |a RANGE OF METABOLIC REAC�ONS OCCURRING WITHIN THE LIVERMETHODS OF DEMONSTRATING HEPAWC FIRST-PASS METABOLISM; RANGE OF DRUGS UNDERGOING EXTENSIVE HEPATIC PRESYSTEMIC METABOLISM; DOSE-DEPENDENT PRESYSTEMIC METABOLISM; VARIATIONS IN HEPATIC PRESYSTEMIC DRUG METABOLISM; CONCLUSIONS; References; Chapter 5. Physiological factors affecting hepatic first-pass metabolism; INTRODUCTION; THE VENOUS EQUILIBRATION MODEL OF HEPATIC ELIMINATION; INTRINSIC CLEARANCE AND FIRST-PASS METABOLISM; LIVER BLOOD FLOW AND FIRST-PASS METABOLISM; BINDING BY BLOOD CONSTITUENTS; FUTURE PERSPECTIVES; CONCLUSIONS. | |