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Chemical structure - biological activity relationships quantitative approaches : proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979 /
Chemical Structure-Biological Activity Relationships: Quantitative Approaches, Volume III, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. This volume focuses on the methodological aspects of QSAR. It also aims to inform the reader about...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Oxford :
Pergamon,
[1980]
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| Colección: | Advances in pharmacological research and practice ;
volume 3. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Chemical Structure-Biological Activity Relationships Quantitative Approaches; Copyright Page; Table of Contents; Preface; List of participants; PART I: PREDICTIVE APPLICATION OF QUANTITATIVE STRUCTURE-ACTNITY RELATIONSHIPS; CHAPTER 1. QSAR OPTIMIZATION OF ACTIVITY, SELECTIVITY AND LACK OF DEPRESSIVITY FOR A BETA-ADRENERGIC BLOCKER. (�)-1-ISOPROPYLAMINO-3-(5-[(C2-endoBICYCLO[3.1.0]HEX-6-YL)-ETHULCARBAMOYL]-2-THIAZOLYLOXY)-PROPAN-2-OL MALEATE; Introduction; References; CHAPTER 2. THE USE OF QSAR IN THE SYNTHESIS OF ANTINFLAMATORY ARYL�ALIRHATIC ACIDS; INTRODUCTION.
- MATERIAL AND METHODSRESULTS AND DISCUSSION; SUMMARY; REFERENCES; CHAPTER 3. BEL FREE: A NEW METHOD FOR PREDICTING BIOLOGICAL ACTIVITY USING INDICATOR VARIABLES; Introduction; Materials and methods; Prediction case studies; Evaluation of the prediction results; BEL FREE method; Discussion; Acknowledgement; References; CHAPTER 4. QUANTITATIVE STRUCTURE
- ACTIVITY
- STUDIES ON SOME PIPERIDINOAC ETANILIDES; Introduction; Material and Methods; Results and discussion; Summary; CHAPTER 5. STRATEGY IN DRUG RESEARCH. STRUCTURE-ACTIVITY RELATIONSHIP OF 11-SUBSTITUTED PROGESTATIONAL STEROIDS.
- IntroductionContinued investigations; Discussion; Literature; PART II: UTILIZATION OF QSAR TOOLS FOR INVESTING PHARMACON-RECEPTOR INTERACTION; CHAPTER 6. THE ROLE OF ANTONIC SITE IN THE SPECIFICITY OF CHOLINESTERASES; Introduction; Methods; Results; Discussion; Summary; References; CHAPTER 7. QSAR OF CHOLINERGIC LIGAND INTERACTIONS; REFERENCES; CHAPTER 8. QSAR OF THE INHIBITION OF CHYMOTRYPSIN BY ALKYL PHOSPHONATES; REFERENCES; CHAPTER 9. 7-SUBSTITUTED-4-HYROXYQUINOLINE-3-CARBOXYLIC ACIDS AS DEHYDROGENASE ENZYME INHIBITORS; INTRODUCTION; MATERIALS AND METHODS; RESULTS AND DISCUSSION; SUMMARY.
- ACKNOWLEDGEMENTREFERENCES; CHAPTER 10. RECEPTOR SITE MAPPING BY MINIMAL STERIC DIFFERENCES; Introduction; Method; Discussion; References; Summary; CHAPTER 11. A SIMPLE MODEL OF DYNAMIC RECEPTOR PATTERN GENERATION; Introduction; Results of the Computer Simulation of the Automaton; Conclusions and Possible Biological Implications of the Model; References; CHAPTER 12. THEORETICAL INVESTIGATION OF THE INHIBITION OF NOREPINEPHRINE REUPTAKE BY PHENYLETHYLAMINE ANALOGUES; Introduction; Method; Results; Discussion; Summary; References; PART III: MATHEMATICAL AND COMPUTATIONAL TOOLS IN QSAR.
- CHAPTER 13. CHANCE FACTORS IN QSAR STUDIESMethod; Results; Applications to Reported Correlation Studies; Summary; Acknoavtedgements; Literature Cited; CHAPTER 14. INLERRELATIONSHIPS BETWEEN BIOLOGICAL ACTIVITIES FROM PARALLEL TESTS IN MASS SCREENING ; Theory and Methods; Results and Discussion; Summary; References; CHAPTER 15. SAMPLE SELECTION METHODS; The PCMM method; The TMIC method; Summary; CHAPTER 16. FACTCR ANALYSIS OF CLINICAL DATA ON THE TREATMENT OF CARDIOVASCULAR DISEASES; Introduction; Method; Summary; References; CHAPTER 17. The Masca Model of Pharmacochemistry; 1. Introduction.