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Neuronal cell death and repair /
Neuronal Cell Death and Repair.
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier,
1993.
|
| Colección: | Restorative neurology ;
v. 6. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Neuronal Cell Death and Repair; Copyright Page; List of Contributors; Preface; Table of Contents; SECTION I: Cellular and Molecular Mechanisms for Neuronal Cell Death; CHAPTER 1. An Introduction to Apoptosis; 1. Introduction; Acknowledgements; References; CHAPTER 2. Apoptosis; 1. Introduction; 2. Classical apoptosis; 3. Mechanisms of apoptosis and programmed cell death; 4. Apoptosis, differentiation and atrophy; 5. Conclusion; References; CHAPTER 3. Molecular mechanism of programmed cell death in the developing nervous system; 1. Introduction.
- 2. Control of neuronal death during development3. Molecular mechanism of neuronal death; 4. Regulation of trophic factor dependence; 5. Concluding comments; Acknowledgments; References; CHAPTER 4. Neurotrophic factors and apoptosis in the nervous system; 1. Developmental neuronal death in vertebrates as a stochastic process regulated by trophic factors; 2. Apoptosis as a possible mode of neuronal cell death; 3. Cultures of PC12 cells and sympathetic neurons as model systems to study neuronal cell death caused by withdrawal of neurotrophic factors.
- 4. Correlation of endonuclease activity with neuronal cell death caused by trophic factor deprivation5. Apoptotic neuronal death after insult; 6. Role of macromolecular synthesis in neuronal death and survival; 7. Signal transduction pathways mediating neuronal survival; 8. Summary, conclusions and further prospects; References; CHAPTER 5. The microtubule cytoskeleton in neuronal development and degeneration; 1. The MAP proteins in morphogenesis and neuronal degeneration; 2. The MAPI protein family; 3. The MAP2 Protein Family; 4. The function and dysfunction of the TAU protein family.
- 5. The significance of MAPs phosphorylation states in neuronal degenerationReferences; CHAPTER 6. Molecular biology and pathology of Alzheimer's disease; 1. Introduction; 2. The amyloid concept; 3. � A4 amyloid protein in the aetiology of Alzheimer's disease; 4. The nature of the ""Alzheimer-specific"" �A4 amyloid protein; 5. Synthetic �A4 amyloid; 6. �A4 amyloid protein deposition at synapses; 7. �A4 protein as biological marker of preclinical Alzheimer's disease; 8. The family of �A4 amyloid protein precursors (APP); 9. Processing of APP to �A4; 10. Function of APP.
- 11. Regulation of the APP gene12. Mechanism and role of amyloid deposition in Alzheimer's disease; Acknowledgments; References; SECTION II: Chemically Induced Neuronal Cell Death; CHAPTER 7. Excitatory amino acids and free radicals in the genesis of ischemic neuronal death; 1. Introduction; 2. Free radicals release EAA; 3. A model of retina ischemia: possible actions of free radicals; 4. Thiokynurenates antagonize neuronal death by acting as NMDA antagonists and as inhibitors of lipoperoxidation.; Acknowledgements; References; CHAPTER 8. Cell death: a tough business; 1. Introduction.