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Pancreatic beta cell. Volume 95, Vitamins and hormones /
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is rel...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, England :
Academic Press,
2014.
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| Colección: | Vitamins and hormones ;
v. 95. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- 1. Overview of Insulin Biosynthesis in Pancreatic Beta Cells2. Proinsulin Entry into the ER; 2.1. Secretory protein translocation into the ER; 2.2. Preproinsulin recognition and targeting to the ER; 2.3. Preproinsulin translocation across the ER membrane; 2.4. Coordination between preproinsulin signal peptide cleavage and downstream proinsulin folding; 2.5. Pancreatic beta cell failure and diabetes caused by defects in some of the earliest events of insulin biosynthesis; 3. Proinsulin Transit Through the ER; 3.1. Proinsulin oxidative folding in the ER; 3.2. Quality control and ER exit
- 4. Physiology and Pathophysiology of Ionic Channels4.1. ATP-sensitive potassium channels; 4.1.1. KATP channels mutation; 4.1.2. KATP in metabolic syndrome; 4.2. Transient receptor potential channels; 4.3. Voltage-gated Na+ channels; 4.4. Voltage-dependent calcium channels; 4.5. Returning to resting potential; 4.6. Calcium release from intracellular reservoirs; 5. Concluding Remarks; References; Chapter Five: The Beta Cell Immunopeptidome; 1. Introduction; 2. Autoantigens in T1D; 3. Antigen Processing; 3.1. Class I presentation; 3.2. Class II presentation; 4. Identifying T Cell Epitopes in T1D