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Advances in immunology Volume 122 /
Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecul...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego, CA :
Academic Press,
2014.
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| Colección: | Advances in immunology.
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| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Advances in Immunology; Copyright; Contents; Contributors; Chapter One: Regulation of Immunoglobulin Class-Switch Recombination: Choreography of Noncoding ... ; 1. Overview of Genomic Alterations in B Cells; 1.1. V(D)J recombination; 1.2. Somatic hypermutation; 1.3. Class-switch recombination; 2. Initiation of CSR: S Regions and Germline Transcription; 2.1. Requirement of S regions in CSR; 2.2. Requirement of germline transcription; 3. Induction of DNA Lesions in CSR: Essential Requirement of AID; 3.1. Discovery of AID; 3.2. AID is a single-strand DNA deaminase.
- 3.3. RNA editing by AID?4. Processing of Deaminated DNA: Requirements for BER and MMR Proteins; 4.1. Removal of uracil residues from deaminated DNA; 4.2. Deamination of the template strand; 4.3. Conversion of ssDNA breaks into DSBs; 5. Completion of CSR: Synapsis and End-Joining; 5.1. S region synapsis; 5.2. DNA end-joining; 6. AID Phosphorylation at Serine-38 and a Role Beyond DNA Deamination; 6.1. Role of AID phosphorylated at Serine-38 in DSB formation; 6.2. Positive feedback loop in amplifying DSBs; 6.3. Role of AID in recruiting RPA to S regions.
- 7. Multifaceted Regulation of AID Expression and Activity7.1. Transcriptional regulation; 7.2. Posttranscriptional control of Aicda mRNA; 7.3. Compartmentalization of AID activity; 7.4. AID phosphorylation; 8. Targeting of AID to the Ig Loci; 8.1. Transcription-dependent AID recruitment; 8.2. GANP and 14-3-3 adaptors; 8.3. PTBP2: An AID interactor that promotes binding to S regions; 9. AID Activity Beyond the Ig Loci; 9.1. AID in B-cell lymphomagenesis; 9.2. AID activity beyond B cells: Epigenetic reprogramming; 10. Perspectives; Acknowledgments; References.
- Chapter Two: Two Forms of Adaptive Immunity in Vertebrates: Similarities and Differences1. Introduction; 2. Discovery of VLR; 3. Structure of VLR Proteins and Genes; 3.1. Protein structure; 3.2. Crystal structure of VLR proteins; 3.3. Gene structure; 3.4. VLR gene assembly; 3.5. Cytidine deaminases involved in gene assembly; 4. Functions of VLR and Lymphocyte Lineages; 4.1. Three populations of lymphocytes in jawless vertebrates; 4.2. Development of agnathan lymphocytes and definition of lymphocyte lineages; 4.3. Tissue distribution of three lineages of lymphocytes.
- 5. Interplay of VLRB and the Complement System6. Similarities and Differences in the Two Forms of Adaptive Immunity; 7. Evolution of Antigen Receptors; 8. Concluding Remarks; Acknowledgments; References; Chapter Three: Recognition of Tumors by the Innate Immune System and Natural Killer Cells; 1. Introduction; 2. Innate Cells and Effector Molecules in Tumor Surveillance; 3. Germline-Encoded Receptors Implicated in Tumor Surveillance; 3.1. NKG2D; 3.2. Other natural cytotoxicity receptors; 3.3. NKp80 (KLRF1); 3.4. SLAM-related receptors; 3.5. Adhesion molecules and DNAM-1.