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Advances in virus research Volume 88 /
The first review series in virology and published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the field. Contributions from leading authoritiesComprehensive reviews for general and specialist useFirst and longest-running review...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego, California :
Academic Press,
2014.
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| Edición: | First edition. |
| Colección: | Advances in virus research ;
v. 88 |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Advances in Virus Research; Copyright; Contents; Contributors; Chapter One: Revisiting Dengue Virus-Host Cell Interaction: New Insights into Molecular and Cellular Virology; 1. Introduction; 2. Dengue Disease; 2.1. History and epidemiology; 2.2. Transmission and course of infection; 2.3. Pathogenesis; 3. The Molecular Biology of DENV; 3.1. An overview of the DENV replication cycle; 3.2. The Dengue virus particle: Biogenesis, release, and entry properties; 3.3. Structural and functional elements of DENV genome; 3.4. Viral proteins and their function; 3.5. Viral RNA replication.
- 4. The DENV-Host Cell Interface: High-Throughput Approaches to Identify Relevant Host Cell Factors and Pathways4.1. Identification of host cell factors of relevance for the DENV replication cycle by using RNAi screens; 4.2. Protein interaction networks; 4.3. Transcriptome, proteome, and lipidome analyses; 4.4. Chemical compounds screens; 5. Host Dependency Factors and Their Role in the DENV Replication Cycle; 5.1. Virus attachment and host cell receptors; 5.2. Mechanism of virus entry and involved host cell pathways; 5.3. RNA translation and replication.
- 5.3.1. Role of autophagy in DENV replication5.3.2. Lipid metabolism and its role in DENV replication; 5.3.3. Role of unfolded protein response and ubiquitin-proteasome system in DENV replication; 5.3.4. RNA-binding host cell factors involved in DENV replication; 5.3.5. Replicase-interacting host cell factors involved in DENV replication; 5.4. Assembly and release; 6. Host Restriction Factors and Their Role in the DENV Replication Cycle; 6.1. PRRs and host cell pathways involved in recognition of DENV infection; 6.2. Inhibition of the IFN system by DENV.
- 6.3. IFN-stimulated genes suppressing DENV replication6.4. Non-IFN pathways involved in suppression of virus replication and hijacked by DENV; 7. Host Cell Factors as Target for Antiviral Agents; 8. Concluding Remarks; Acknowledgments; References; Chapter Two: KSHV: Pathways to Tumorigenesis and Persistent Infection; 1. Malignancies and Syndromes Linked with KSHV Infection; 1.1. Kaposi� s sarcoma; 1.2. Primary effusion lymphoma; 1.3. Multicentric Castleman� s disease; 1.4. KSHV-associated inflammatory cytokine syndrome; 1.5. KSHV immune reconstitution inflammatory syndrome.
- 2. KSHV Biology: Virion, Transmission, and Viral Lifecycle2.1. Viral latency and associated proteins; 2.1.1. LANA; 2.1.2. vCyclin; 2.1.3. vFLIP; 2.1.4. The kaposins; 2.1.5. KSHV microRNAs; 2.2. KSHV lytic cycle; 3. Lytic KSHV Proteins Involved in Cell Growth and Survival; 3.1. K1; 3.2. Viral G-protein-coupled receptor; 3.3. Viral interleukin-6; 3.4. K15; 4. KSHV� s Activation and Evasion of the Host Immune Response; 4.1. Immune activation; 4.2. Evasion of the adaptive immune response; 4.3. Evasion of the innate immune response; 4.3.1. Interferon and IRF inhibition by KSHV.