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Cellular endocrinology in health and disease /

Cellular Endocrinology in Health and Disease describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Ulloa-Aguirre, Alfredo, Conn, P. Michael
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press, 2014.
Temas:
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Hypothyroidism Retards Tumor Growth but Increases Metastasis DevelopmentDivergent Effects of TRs on Normal and Transformed Cell Proliferation; Acknowledgements; References; 2 The Molecular Cell Biology of Anterior Pituitary Cells; Introduction; Anterior Pituitary: Organization, Cell Types, Hormones and Functions; Diseases of the Anterior Pituitary; Hypopituitarism; ACTH Deficiency; TSH Deficiency; LH, FSH Deficiencies; GH Deficiency; PRL Deficiency; Hyperpituitarism; Prolactinoma; Corticotropinoma; Somatotropinoma; Null Cell Adenomas; Gonadotrophic Adenomas; Thyrotrophic Adenomas
  • Phenotypic Profile of Anterior Pituitary Cell Types: Different, Yet Somewhat SimilarHeterogeneity within Anterior Pituitary Cell Types: Similar, Yet Somewhat Different; Patterns of Anterior Pituitary Cell Signaling and Secretion; Molecular Mechanisms Underlying Excitability and Basal Secretion; Receptor-Modulated Hormone Release and Voltage-Gated Ca2+ Influx through cAMP-Dependent Pathways; Receptor-Modulated Hormone Release through Ca2+-Mobilizing Pathways; Paracrine (Local) Regulation and Intercellular Signaling within the Anterior Pituitary
  • Plasticity of Anterior Pituitary Cell Network Organization and FunctionConcluding Remarks; Acknowledgements; References; 3 Sensing Calcium Levels: The Biology of the Parathyroid Cell; Introduction; Biosynthesis and Metabolism of PTH; Regulation of PTH Secretion and Transcription; Calcium-Sensing Properties of the Parathyroids: The CaSR; Phospate/FGF23 Regulation of the Parathyroids; Vitamin D Regulation of the Parathyroids; Main Mechanisms of Parathyroid Gland Hyperplasia in SHPT; Conclusions; References; 4 The Biology of Pituitary Stem Cells; Introduction
  • Location of Proliferating and Differentiating Cells During Pituitary DevelopmentStrategies for Identifying Pituitary Progenitors; Chromophobes Can Differentiate into All Anterior Pituitary Hormone-producing Cells; Pituitary Progenitors Absorb a Fluorescent Dipeptide and Have Folliculostellate Cell Characteristics; Pituitary Progenitors in the Side Population That Exhibit Rapid Hoechst Dye Efflux; Pituitary Progenitors in the SOX2-Positive Cell Population; Pituitary Progenitors Expressing GFRa2 and PROP1: Rodent and Human; Nestin-GFP Tagged Pituitary Progenitors