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Advances in immunology Volume 121 /
Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecul...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Academic Press,
2013.
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| Colección: | Advances in immunology.
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| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Advances in Immunology; Copyright; Contents; Contributors; Chapter One: Multifarious Determinants of Cytokine Receptor Signaling Specificity; 1. Introduction; 2. Ligand-Receptor Complex Formation: Geometry and Affinity; 2.1. Surface receptor complex geometry and signal activation; 2.2. Ligand-receptor affinity: Stability of the ternary complex; 2.3. Ligand-receptor affinity: Kinetics of complex formation; 3. Receptor Dynamics and Endosomal Trafficking; 4. Intracellular Protein Levels and Signaling Activation; 4.1. Jaks and receptor expression and affinity
- 4.2. Crosstalk between STATs5. Tuning Cytokine Signaling via Protein Engineering; 5.1. Modulation of trafficking: IL-2 and EGF; 5.2. Modulation of ligand affinity and activities: IFN and IL-3; 5.3. Increasing ligand specificity: IL-2 and IL-4; 6. Perspectives; Acknowledgments; References; Chapter Two: Pathogenic Mechanisms of Bradykinin Mediated Diseases: Dysregulation of an Innate Inflammatory Pathway; 1. Introduction; 2. Contact Activation: Factor XII-Dependent Initiation of Bradykinin Formation; 3. Assembly on Cell Surfaces: Binding of HK to HUVEC; 4. Binding of Factor XII to HUVEC
- 5. Interaction of gC1qR, Cytokeratin 1, and u-PAR Within HUVEC Cell Membranes6. Binding to Other Cells; 7. Activation of the Kinin Cascade: The Role of Endothelial Cells; 7.1. Activation by binding to the cell surface; 7.2. Factor XII-independent activation of the PK-HK complex on endothelial cells; 8. Inhibition of Contact Activation; 9. Inactivation of Bradykinin; 10. Further Considerations of the Initiating Site for Bradykinin Formation: Evidence That the PK-HK Complex has Enzymatic...; 11. Hereditary Angioedema (Types I and II=C1 Inhibitor Deficiency)
- 12. Bradykinin Formation When C1 INH is Absent/Dysfunctional13. Type III HAE; 14. New Modalities for Treatment of HAE; 15. Proteoglycan-Dependent Activation of Factor XII: Theoretical Mechanisms for Bradykinin Production in ``Allergic� � Dis...; 16. Activation of Factor XII by Aggregated Proteins; References; Chapter Three: The Role of Short-Chain Fatty Acids in Health and Disease; 1. Introduction; 1.1. The production of SCFAs; 1.1.1. Substrates for SCFA production; 1.1.2. Mechanism of SCFA production; 1.1.3. Manipulation of SCFA production via modulation of microbiota; 1.2. Transport of SCFAs
- 2. SCFA Sensing and Signal Transduction2.1. HDAC inhibitors; 2.1.1. Mechanism behind SCFA-mediated HDAC inhibition; 2.1.2. Immunological relevance of SCFA-mediated HDAC inhibition; 2.2. G-protein-coupled receptors; 2.2.1. GPR43; 2.2.2. GPR41; 2.2.3. GPR109A; 3. Varied Functions of SCFAs; 3.1. Anti-inflammatory and antitumorigenic roles; 3.2. SCFAs and antimicrobial activities; 3.3. SCFAs and gut integrity; 4. Integrative View of the Gut Microbiota, SCFAs, and Disease; 5. Perspective; References; Chapter Four: Combined Immunodeficiencies with Nonfunctional T Lymphocytes; 1. Introduction