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Prion diseases and copper metabolism : BSE, scrapie, and CJD research /
International authorities here investigate research into the prion diseases which include Scrapie of sheep, BSE the "Mad Cow" disease, and CJD one of the human diseases. The role of metals in these diseases has become of great importance, linking it with some of the changes in Alzheimer�...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Chichester :
Horwood Pub.,
[2002]
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| Colección: | Horwood Publishing series: Infectious diseases and microbiology.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Dedication; Prion Diseases and Copper Metabolism: BSE, Scrapie and CJD Research; Copyright Page; Address of Corresponding or Main Authors; Table of Contents; Chapter 1. Introduction; 1.1 TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES; 1.2 COPPER AND PRION DISEASE; 1.3 PRION DISEASE AND METALLOPROTEINS; Chapter 2. Copper
- Prion Protein, Molecular Interactions; 2.1 INTRODUCTION; 2.2 THE PRION PROTEIN; 2.3 SYNAPTIC EXPRESSION; 1.4 PRION PROTEIN AND CU UPTAKE; 1.5 PRION PROTEIN AS A SUPEROXIDE DISMUTASE; 2.6 CONFORMATIONAL CORRUPTION OF THE PRION PROTEIN BY METALS; 2.7 CONCLUSION.
- Chapter 3. The Effects of Copper on the Cellular Trafficing and Biochemical Properties of the Prion Protein3.1 ABSTRACT; 3.2 INTRODUCTION; 3.3 EFFECTS OF COPPER ON THE CELLULAR TRAFFICKING OF PRP; 3.4 COPPER AND CUPROENZYME LEVELS IN MICE EXPRESSING DIFFERENT AMOUNTS OF PRP; 3.5 EFFECTS OF COPPER ON THE BIOCHEMICAL PROPERTIES OF PRP; 3.6 CONCLUSIONS; 3.7 ACKNOWLEDGEMENTS; Chapter 4. Tracing the Copper Binding to the Murine Prion Protein using Electron Paramagnetic Resonance; 4.1 ABSTRACT; 4.2 INTRODUCTION; 4.3 ABOUT THE TECHNIQUES; 4.4 PREPARATION OF THE SAMPLES.
- 4.5 CU2+ BINDING TO THE OCTAPEPTIDE REPEAT REGION OF THE MURINE PRION PROTEIN4.6 EVIDENCE OF CU2+ BINDING TO THE C-TERMINAL PART OF THE PROTEIN; 4.7 UNRAVELLING THE CU2+ BINDING SITES IN THE C-TERMINAL DOMAIN; 4.8 DOES THE COPPER BINDING CHANGE AFTER MUTATION OF THE PRION PROTEIN?; 4.9 POSSIBLE BIOLOGICAL IMPLICATIONS; 4.10 CONCLUSIONS; 4.11 ACKNOWLEDGEMENTS; Chapter 5. Co-ordinate Binding of Copper to Prion Protein; 5.1 INTRODUCTION; 5.2 COPPER CO-ORDINATION; 5.2 WHERE DOES COPPER BIND?; 5.3 EARLY VIEWS; 5.4 AN EARLY CRYSTAL STRUTURE; 5.5 CONCLUSION.
- Chapter 6. Oxidative Stress, Metal Ions and Neurodegenerative Diseases6.1. INTRODUCTION; 6.2. OXIDATIVE STRESS IN CNS DISEASE; 6.3. OXIDATIVE STRESS AND TSES; 6.4. METALS IN TSES; 6.5. METALS IN OTHER NEUROLOGICAL DISEASES; 6.6. CONCLUSION; Chapter 7. Near Infrared Spectroscopy for Nondestructive Study of Prion Protein Isoforms; 7.1 INTRODUCTION; 7.2 NEAR INFRARED SPECTROSCOPY: BACKGROUND; 7.3 NIR SPECTRAL DATA MULTIVARIATE ANALYSIS. CHEMOMETRICS; 7.4 NIRS FOR NONDESTRUCTIVE FUNCTIONAL ANALYSIS OF PRION PROTEINS.
- Chapter 8. Prion and Alzheimer Diseases: The Road to Pathogenesis is Paved with Copper8.1 PRION DISEASES; 8.2 PRION DISEASE AND ALZHEIMER DISEASE: PATHOGENIC OVERLAP; Chapter 9. The Copper Binding Domain of the Amyloid Precursor Protein of Alzheimer's Disease can Modulate Copper Homeostasis and Regulate Amyloid A� Production; 9.1 INTRODUCTION; 9.2 DIMERIZATION AND STABILITY OF APP ISOFORMS: INFLUENCE OF METAL ION BINDING TO APP ON RELATIVE STABILITY AND METABOLISM; 9.3 THE ROLE OF COPPER IN THE PATHOLOGICAL FUNCTION OF THE AMYLOID PRECURSOR PROTEIN (APP).