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Prion diseases and copper metabolism : BSE, scrapie, and CJD research /
International authorities here investigate research into the prion diseases which include Scrapie of sheep, BSE the "Mad Cow" disease, and CJD one of the human diseases. The role of metals in these diseases has become of great importance, linking it with some of the changes in Alzheimer�...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Chichester :
Horwood Pub.,
[2002]
|
| Colección: | Horwood Publishing series: Infectious diseases and microbiology.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 003 | OCoLC | ||
| 005 | 20231120111518.0 | ||
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| 008 | 140128s2002 enka ob 000 0 eng d | ||
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| 019 | |a 871225211 |a 874158159 | ||
| 020 | |a 9780857099914 |q (electronic bk.) | ||
| 020 | |a 0857099914 |q (electronic bk.) | ||
| 020 | |z 9781898563877 | ||
| 020 | |z 189856387X | ||
| 035 | |a (OCoLC)869282433 |z (OCoLC)871225211 |z (OCoLC)874158159 | ||
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| 082 | 0 | 4 | |a 616.8 |2 22 |
| 245 | 0 | 0 | |a Prion diseases and copper metabolism : |b BSE, scrapie, and CJD research / |c David R. Brown [editor]. |
| 264 | 1 | |a Chichester : |b Horwood Pub., |c [2002] | |
| 264 | 4 | |c �2002 | |
| 300 | |a 1 online resource (viii, 250 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Horwood Publishing series: Infectious diseases and microbiology | |
| 504 | |a Includes bibliographical references (pages 195-250). | ||
| 588 | 0 | |a Print version record. | |
| 520 | |a International authorities here investigate research into the prion diseases which include Scrapie of sheep, BSE the "Mad Cow" disease, and CJD one of the human diseases. The role of metals in these diseases has become of great importance, linking it with some of the changes in Alzheimer's disease. The book focuses on metabolism of copper and manganese which are found in these diseases. It stems from proceedings of the international workshop at Christ's College, Cambridge University in 2001. After an introduction on the history of research into the diseases, there are discussions on the effects of copper on biochemical properties and prion proteins of brain cells, and newer techniques for their study. There is also a section on the relationship of Alzheimers disease to prion diseases. Focuses on metabolism of copper and manganese, which are found in Scrapie of sheep; BSE, the "Mad Cow" disease; and CJD, one of the human prion diseasesDiscusses the effects of copper on biochemical properties, prion proteins of brain cells and new techniques for their studyStems from the proceedings of the international workshop at Christ's College, Cambridge University in 2001. | ||
| 505 | 0 | |a Front Cover; Dedication; Prion Diseases and Copper Metabolism: BSE, Scrapie and CJD Research; Copyright Page; Address of Corresponding or Main Authors; Table of Contents; Chapter 1. Introduction; 1.1 TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES; 1.2 COPPER AND PRION DISEASE; 1.3 PRION DISEASE AND METALLOPROTEINS; Chapter 2. Copper -- Prion Protein, Molecular Interactions; 2.1 INTRODUCTION; 2.2 THE PRION PROTEIN; 2.3 SYNAPTIC EXPRESSION; 1.4 PRION PROTEIN AND CU UPTAKE; 1.5 PRION PROTEIN AS A SUPEROXIDE DISMUTASE; 2.6 CONFORMATIONAL CORRUPTION OF THE PRION PROTEIN BY METALS; 2.7 CONCLUSION. | |
| 505 | 8 | |a Chapter 3. The Effects of Copper on the Cellular Trafficing and Biochemical Properties of the Prion Protein3.1 ABSTRACT; 3.2 INTRODUCTION; 3.3 EFFECTS OF COPPER ON THE CELLULAR TRAFFICKING OF PRP; 3.4 COPPER AND CUPROENZYME LEVELS IN MICE EXPRESSING DIFFERENT AMOUNTS OF PRP; 3.5 EFFECTS OF COPPER ON THE BIOCHEMICAL PROPERTIES OF PRP; 3.6 CONCLUSIONS; 3.7 ACKNOWLEDGEMENTS; Chapter 4. Tracing the Copper Binding to the Murine Prion Protein using Electron Paramagnetic Resonance; 4.1 ABSTRACT; 4.2 INTRODUCTION; 4.3 ABOUT THE TECHNIQUES; 4.4 PREPARATION OF THE SAMPLES. | |
| 505 | 8 | |a 4.5 CU2+ BINDING TO THE OCTAPEPTIDE REPEAT REGION OF THE MURINE PRION PROTEIN4.6 EVIDENCE OF CU2+ BINDING TO THE C-TERMINAL PART OF THE PROTEIN; 4.7 UNRAVELLING THE CU2+ BINDING SITES IN THE C-TERMINAL DOMAIN; 4.8 DOES THE COPPER BINDING CHANGE AFTER MUTATION OF THE PRION PROTEIN?; 4.9 POSSIBLE BIOLOGICAL IMPLICATIONS; 4.10 CONCLUSIONS; 4.11 ACKNOWLEDGEMENTS; Chapter 5. Co-ordinate Binding of Copper to Prion Protein; 5.1 INTRODUCTION; 5.2 COPPER CO-ORDINATION; 5.2 WHERE DOES COPPER BIND?; 5.3 EARLY VIEWS; 5.4 AN EARLY CRYSTAL STRUTURE; 5.5 CONCLUSION. | |
| 505 | 8 | |a Chapter 6. Oxidative Stress, Metal Ions and Neurodegenerative Diseases6.1. INTRODUCTION; 6.2. OXIDATIVE STRESS IN CNS DISEASE; 6.3. OXIDATIVE STRESS AND TSES; 6.4. METALS IN TSES; 6.5. METALS IN OTHER NEUROLOGICAL DISEASES; 6.6. CONCLUSION; Chapter 7. Near Infrared Spectroscopy for Nondestructive Study of Prion Protein Isoforms; 7.1 INTRODUCTION; 7.2 NEAR INFRARED SPECTROSCOPY: BACKGROUND; 7.3 NIR SPECTRAL DATA MULTIVARIATE ANALYSIS. CHEMOMETRICS; 7.4 NIRS FOR NONDESTRUCTIVE FUNCTIONAL ANALYSIS OF PRION PROTEINS. | |
| 505 | 8 | |a Chapter 8. Prion and Alzheimer Diseases: The Road to Pathogenesis is Paved with Copper8.1 PRION DISEASES; 8.2 PRION DISEASE AND ALZHEIMER DISEASE: PATHOGENIC OVERLAP; Chapter 9. The Copper Binding Domain of the Amyloid Precursor Protein of Alzheimer's Disease can Modulate Copper Homeostasis and Regulate Amyloid A� Production; 9.1 INTRODUCTION; 9.2 DIMERIZATION AND STABILITY OF APP ISOFORMS: INFLUENCE OF METAL ION BINDING TO APP ON RELATIVE STABILITY AND METABOLISM; 9.3 THE ROLE OF COPPER IN THE PATHOLOGICAL FUNCTION OF THE AMYLOID PRECURSOR PROTEIN (APP). | |
| 650 | 0 | |a Prion diseases. | |
| 650 | 0 | |a Copper |x Therapeutic use. | |
| 650 | 1 | 2 | |a Prion Diseases |x etiology |0 (DNLM)D017096Q000209 |
| 650 | 2 | |a Prion Diseases |0 (DNLM)D017096 | |
| 650 | 2 | 2 | |a Copper |x metabolism |0 (DNLM)D003300Q000378 |
| 650 | 6 | |a Maladies �a prions. |0 (CaQQLa)201-0027661 | |
| 650 | 6 | |a Cuproth�erapie. |0 (CaQQLa)201-0074661 | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x General. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Clinical Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Diseases. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Evidence-Based Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Internal Medicine. |2 bisacsh | |
| 650 | 7 | |a Copper |x Therapeutic use |2 fast |0 (OCoLC)fst00878412 | |
| 650 | 7 | |a Prion diseases |2 fast |0 (OCoLC)fst01076975 | |
| 700 | 1 | |a Brown, David R. |q (David Ronald), |d 1964- | |
| 776 | 0 | 8 | |i Print version: |t Prion diseases and copper metabolism |z 9781898563877 |w (OCoLC)52236114 |
| 830 | 0 | |a Horwood Publishing series: Infectious diseases and microbiology. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9781898563877 |z Texto completo |