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Glucose Homeostatis and the Pathogenesis of Diabetes Mellitus /
Diabetes mellitus is a disease with tremendous health and economic burden. A better understanding of how normal glucose homeostasis is maintained and the pathogenesis is important to identify new ways for diabetes treatment. This book addresses multiple aspects of this area of research. Key features...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press,
�2014.
|
| Edición: | First edition. |
| Colección: | Progress in molecular biology and translational science ;
v. 121. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Glucose Homeostatis and the Pathogenesis of Diabetes Mellitus; Copyright; Contents; Contributors; Preface; Chapter One: G Protein-Coupled Receptors as Regulators of Glucose Homeostasis and Therapeutic Targets for Diabetes Mellitus; 1. Introduction; 2. Regulation of Glucose Homeostasis by GPCRs in the Central Nervous System; 3. Regulation of Glucose Homeostasis by GPCRs for Peptides from Endocrine Pancreas; 4. Regulation of Insulin Secretion by GPCRs; 5. Regulation of Incretin Secretion by GPCRs; 6. Regulation of Glucose Homeostasis by Orphan GPCRs; 7. Summary; Acknowledgments
- 12. Safety Considerations for GLP-1-Based Therapeutics13. Conclusion; Acknowledgments; References; Chapter Three: Physiology and Therapeutics of the Free Fatty Acid Receptor GPR40; 1. Introduction; 2. Molecular Cloning and Tissue Distribution of GPR40; 2.1. Molecular cloning; 2.2. Tissue distribution; 3. Physiology of GPR40; 3.1. Insulin secretion and glucolipotoxicity; 3.2. Incretin secretion; 3.3. Glucagon secretion; 3.4. Inflammation; 3.5. Bone density; 3.6. Neurogenesis and pain control; 3.7. Cell proliferation; 3.8. Taste preference; 4. Pharmacology of GPR40
- 4. Pharmacology of GPR1194.1. Ligand development and receptor activation; 4.2. Signaling pathways and regulation; 5. Conclusions; Acknowledgments; References; Chapter Five: Enhanced Skeletal Muscle for Effective Glucose Homeostasis; 1. Introduction; 2. Skeletal Muscle and Glucose Homeostasis; 3. Skeletal Muscle Formation; 4. Myogenic Regulatory Factors; 5. Postnatal Development of Skeletal Muscle; 6. Myostatin and Skeletal Muscle Mass; 7. Enhanced Muscle Growth for Preventing Diabetes; 8. Concluding Remarks; Acknowledgments; References