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Electrocardiography of laboratory animals /
Electrocardiography of Laboratory Animals is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countries institute requirements for the care of laboratory animals in research, this publication offers an effective standard on...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier/AP,
�2014.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Electrocardiography of Laboratory Animals; Copyright Page; Dedication; Contents; Preface; Foreword; Acknowledgements; 1 Electrocardiography in Preclinical Safety; Introduction; Regulatory Guidance versus Good Science versus Rationale Drug Development; What To Do When?; Safety Pharmacology versus Toxicology; Safety Pharmacology Studies: Core-Battery and Second-Tier Testing for Cardiotoxicity; Why Study Electrocardiography Preclinically?; Typical Cardiovascular Safety Pharmacology Designs; Rising-Dose Design; Advantages; Disadvantages; 4-Way Crossover/Latin Square Design
- AdvantagesDisadvantages; Cardiotoxicity Endpoints in Toxicology; Regarding ECGs; Serum Enzymes; Postmortem Evaluations; The ECG and Drug Safety; 2 Principles of Electrocardiography; Recording the ECG; Cardiac Conduction and Waveform Genesis; Evaluation of the Electrocardiogram; Transmembrane Action Potentials; Evaluation of Waveforms; Mean Electrical Axis; Equipment Considerations; Cardiac Effects of Systemic Potassium and Calcium Abnormalities; Hypokalemia; Hyperkalemia; Hypocalcemia; Hypercalcemia; 3 Canine Electrocardiography; Introduction; Etiology, Pathophysiology, and Gross Pathology
- Rhythm DiagnosisNormal Sinus Rhythm; Sinus Tachycardia; Sinus Bradycardia; Respiratory Sinus Arrhythmia; Premature Atrial Complexes; Atrial Tachycardia (AT); Atrial Fibrillation; Premature Ventricular Complexes; Accelerated Idioventricular Rhythm; Ventricular Tachycardia; Ventricular Flutter, Ventricular Fibrillation; Ventricular Asystole; Atrioventricular Block; Atrial Standstill (Silent Atrium); Sinus Node Dysfunction (Sick Sinus Syndrome, Bradycardia-Tachycardia Syndrome); Ventricular Preexcitation and Macro Reentry; 4 Handling and Restraint of Nonhuman Primates; Cynomolgus and Rhesus
- Manual RestraintPhysical Restraint; Machine Setup and Configuration; Lead Placement; Obtaining the Tracing; Chemical Restraint; Tracing Handling and Storage; 5 Electrocardiography of Nonhuman Primates; Fundamental Principles of Electrocardiography; Basic Electrocardiographic Physiology; Cardiac Conduction System and the Electrocardiogram; Electrocardiography of Cynomolgus and Rhesus Monkeys; Introduction; Normal Sinus Rhythm; Normal Variants; Cardiac Arrhythmias; Sinoatrial Arrhythmias; Sinus Tachycardia; Sinus Arrhythmia; Sinoatrial Block and Sinus Arrest; Wandering Pacemaker
- Sinus BradycardiaSupraventricular Arrhythmias; Atrial Premature Complexes; Atrial Tachycardia; Atrial Flutter; Atrial Fibrillation; Junctional Premature Contraction; Junctional Tachycardia; Ventricular Arrhythmias; Ventricular Premature Complexes (VPCs); Ventricular Escape Complexes; Terminology; Ventricular Tachycardia; Ventricular Fibrillation; Torsades de Pointes; Ventricular Preexcitation; Abnormalities of Impulse Conduction; Sinoatrial Standstill; First-Degree Atrioventricular Block; Second-Degree Atrioventricular Block; Third-Degree Atrioventricular Block; Bundle Branch Blocks