A history of modern immunology : the path toward understanding /

A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers....

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Nagy, Zoltan A.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Elsevier Science, 2014.
Temas:
Immunology > History.
Allergy and Immunology > history
Immunologie > Histoire.
SCIENCE > Life Sciences > Anatomy & Physiology.
Immunology
History
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; A History of Modern Immunology :The Path Toward Understanding; Copyright; Dedication; Contents; Introductory Words About Science, Scientists, and Immunology; REFERENCE; Part I
  • Pre-history with Far-reaching Consequences; Chapter 1
  • The Immunological Revolution; 1.1 THE CLONAL SELECTION THEORY; 1.2 THE BIRTH OF B AND T LYMPHOCYTES; 1.3 T-B CELL COLLABORATION; 1.4 THE STRUCTURE OF IMMUNOGLOBULINS; 1.5 ALLERGY: FROM DISEASE SYMPTOMS TO IGE; REFERENCES; Part II
  • The History; Chapter 2
  • A Very Special Location: The Basel Institute for Immunology; REFERENCE.
  • Chapter 3
  • Immunological SpecificityREFERENCES; Chapter 4
  • Monoclonal Antibodies: The Final Proof for Clonal Selection; 4.1 DISCOVERY; 4.2 IMMUNOLOGY GOES BUSINESS; 4.3 THE TECHNOLOGY AVALANCHE: ANTIBODY ENGINEERING; References; Chapter 5
  • The First Victory of Molecular Biology: Mechanisms of the Generation of Antibody Diversity; 5.1 THEORETICAL TREATMENT OF THE PROBLEM; 5.2 THE EXPERIMENTAL SOLUTION; 5.3 WHAT DID WE LEARN FROM THE MECHANISMS OF GOD?; 5.4 A BAROQUE EMBELLISHMENT OF ANTIBODY DIVERSITY: THE IDIOTYPE NETWORK; REFERENCES; Chapter 6
  • The Major Histocompatibility Complex.
  • 6.1 MHC CLASS I6.2 MHC CLASS II; 6.3 Sorting Out the Genetics of MHC; REFERENCES; Chapter 7
  • Antigen Processing and Presentation; 7.1 THE RULES OF PEPTIDE BINDING TO MHC MOLECULES; 7.2 The Most Revealing Crystallographic Study in the History of Immunology: the Three-Dimensional Structure of MHC Molecules; 7.3 ANTIGEN PROCESSING AND LOADING PATHWAYS; 7.4 THE CASE FOR A SPECIALIZED ANTIGEN-PRESENTING CELL; 7.5 Antigen Processing and Presentation: Phenomena that Beg for a Concept; REFERENCES; Chapter 8
  • The Intricate Behavior of T Cells.
  • 8.1 MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION OF T-CELL RECOGNITION8.2 Chase for the Antigen Receptor of T Cells; 8.3 T-CELL RECOGNITION: FROM FACTS TOWARD UNDERSTANDING; 8.4 Thymus and the T-Cell Repertoire; 8.5 Alloreactivity: the Continuing Puzzle; 8.6 FUNCTIONAL SUBCLASSES OF T CELLS; 8.7 Cell Adhesion, Costimulation, Co-Inhibition; REFERENCES; Chapter 9
  • Acquired Immunological Tolerance; 9.1 DISCOVERY; 9.2 THE ERA OF THEORIES; 9.3 THE ERA OF MECHANISTIC STUDIES; 9.4 Can Self Tolerance be Understood?; References; Chapter 10
  • Autoimmunity.
  • 10.1 GENETIC FACTORS PREDISPOSING TO AUTOIMMUNE DISEASE10.2 HOW IS AUTOIMMUNITY INITIATED?; 10.3 Some Aspects of Pathogenesis; 10.4 APPROACHES TO IMMUNOTHERAPY; 10.5 What is Needed for Better Understanding of Autoimmunity?; References; Concluding Remarks; Index.

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