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International review of cell and molecular biology. Volume three hundred and six /
International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transfor...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego, CA :
Academic Press,
2013.
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| Edición: | First edition. |
| Colección: | International review of cell and molecular biology,
volume three hundred and six |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; International Review of Cell and Molecular Biology; Copyright; Contents; Contributors; Chapter One: Cell and Molecular Biology of DNA Methyltransferase 1; 1. Introduction; 2. Positions of Genomic 5-Methyl-Cytosines and Their Significance; 2.1. Symmetric and asymmetric cytosine methylation in plants and animals; 2.2. Significance of symmetric methylation; 2.3. Holliday/Pugh and Riggs postulates for inheritance of symmetric cytosine methylation; 2.4. Experimental support for maintenance methyltransferase activity; 3. Basic Molecular Mechanisms of Maintenance Methylation
- 3.1. Basic chemistry of enzymatic reaction3.2. Similarities and differences in plant and animal maintenance methyltransferases; 3.2.1. Amino acid sequence alignments; 3.2.2. Preferences for hemimethylated DNA; 3.3. Structured, highly conserved regions of DNMT1 and possible functions; 3.4. Role of accessory and interacting proteins in DNMT1 methyltransferase function; 3.5. Intrinsically disordered region of DNMT1 and possible functions; 3.6. Roles of posttranslational modifications to DNMT1; 4. Genomic Methylation During Plant and Animal Life Cycles
- 4.1. Patterns of symmetric methylation during mouse development4.2. Developmental patterns require de novo methylation, maintenance methylation, and demethylation; 4.3. Regulation of Dnmt1 expression; 4.4. DNMT1s role in imprinting; 4.5. DNMT1 and development; 4.6. Roles for Dnmt1 in DNA repair and radiation-induced DNA damage; 5. Demethylation; 5.1. Lessons from plants-Developmental, biochemical, and genetic studies; 5.2. Evidence for active demethylation in animals; 5.3. Active versus passive demethylation; 5.4. Regulating DNMT1 and demethylation; 6. De Novo Methylation
- 6.1. Lessons from plants-Biochemical and genetic studies6.2. De novo methylation mechanisms in animals; 7. Concluding Remarks; References; Chapter Two: Endothelial Progenitor Cells-Potential New Avenues to Improve Neoangiogenesis and Reendothelialization; 1. Introduction; 2. Characterization of EPC; 2.1. Isolation of EPCs; 2.1.1. Hematopoietic stem cells; 2.1.2. Early EPC/circulating angiogenic cells; 2.1.3. Late EPC/ECFC; 2.1.4. Colony-forming units according to Hill et al.; 2.1.5. MC, which differentiate into ECs under the influence of cultivation factors
- 2.1.6. Other CPCs, termed ``side population cells� � or tissue resident progenitor cells2.1.7. Circulating mature ECs that are sheared off from vessel walls; 2.2. Phenotypical characterization; 2.3. Genetic characterization; 2.4. Effects of cytokines on EPC; 2.4.1. Vascular endothelial growth factor; 2.4.2. SDF-1; 2.4.3. G-CSF/GM-CSF; 2.4.4. TNF-alpha; 2.4.5. Other cytokines and hormones; 2.4.5.1. Erythropoietin; 2.4.5.2. Estradiol; 2.4.5.3. MIF; 2.5. Cytokines expressed by EPC; 3. EPC in Health and Disease; 3.1. EPC in the healthy; 3.2. EPC in disease; 3.2.1. Cardiovascular disease