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Advances in molecular toxicology. Volume seven /
Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Oxford, UK :
Elsevier,
2013.
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| Edición: | First edition. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Advances in Molecular Toxicology; Copyright; Contents; Contributors; Preface; Chapter One: AHR- and ER-Mediated Toxicology and Chemoprevention; 1. Introduction; 2. AHR Ligands; 2.1. Natural and/or dietary ligands; 2.2. Endogenous ligands; 3. Aryl Hydrocarbon Receptor; 3.1. Mechanism of AHR transactivation; 3.2. The nongenomic pathway; 3.3. Negative feedback regulation of AHR transactivation; 3.4. AHR-regulated signaling and toxicity; 3.5. Adverse human health effects of dioxin-like compounds; 3.6. Adaptive response pathway; 3.7. Developmental pathway
- 6.2. Phenylenediamine arylamine xenobiotics7. Arylamine Drugs and Blood Dyscrasias; 7.1. Procainamide; 7.2. Aminoglutethimide; 7.3. Aminopyrine; 8. Diverting Toxic Arylamine Free Radical Generation to Detoxification: Importance of Free Radical Targets; 9. Mixtures Toxicology-Application to Arylamine Free Radicals; 10. Protein Radicals and Toxicity-Future Prospects; 11. Closing Remarks; References; Chapter Three: Genotoxicity of Polycyclic Aromatic Hydrocarbon Metabolites: Radical Cations and Ketones; 1. Introduction; 2. Exposure to PAHs; 3. Exposure Risks of PAH; 4. DNA Damage by PAH
- 5. PAH Metabolism to DNA-Reactive Metabolites6. Diol-Epoxide Pathway; 7. The Radical Cation Pathway; 8. Depurinating PAH Adducts and AP Sites; 9. Mutagenesis Studies to Address PAH Radical Cations; 10. Evidence for AP Site Formation Due to Radical Cations; 11. Mutagenicity Studies with B[a]P Radical Cation Products; 12. The Quinone Pathway; 13. Exposure to OPAHs; 14. Biological Relevance of OPAH; 15. Conclusion; References; Chapter Four: Nitrogen Oxides Toxicology of the Aerodigestive Tract; 1. Introduction; 2. Chemistry of Reactive Oxygen and Nitrogen Oxide Species and the Scavengers