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Strategies and tactics in organic synthesis. Volume 9 /

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, we are given stories that vividly demo...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Harmata, Michael, 1959- (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Academic Press, 2013.
Temas:
Acceso en línea:Texto completo
Texto completo

MARC

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245 0 0 |a Strategies and tactics in organic synthesis.  |n Volume 9 /  |c edited by Michael Harmata. 
260 |a Amsterdam :  |b Academic Press,  |c 2013. 
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520 |a A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, we are given stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This book series shows how synthesis is really done, and we are educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world. Presents state-of-the-art developments in organic synthesisProvides insight and offers new perspective to problem-solvingWritten by leading experts in the field. 
500 |a Includes index. 
588 0 |a Print version record. 
505 0 |a Machine generated contents note: 1. Total Synthesis of Strychnos Alkaloids Akuammicine, Strychnine, and Leuconicines A and B / Rodrigo B. Andrade -- 1. Introduction and Overview -- 2. Background on the Synthesis of Strychnine and Our Retrosynthesis -- 3. Selected Strategies for Preparing the ABCE Tetracyclic Framework of Strychnos and Aspidosperma Alkaloids -- 4. Selected Bis-Cyclization Approaches -- 5. Our Approach to the ABCE Tetracycle -- 6. Racemic Syntheses of Akuammicine and Strychnine -- 7. Asymmetric Preparation of the ABCE Tetracycle -- 8. Asymmetric Syntheses of Leuconicines A and B -- Acknowledgments -- References -- 2. Total Synthesis of the Unusual Peptide Celogentin C / Bing Ma -- 1. Introduction -- 2. First Synthetic Plan and Initial Studies -- 3. Synthesis of the Right-Hand Ring via Oxidative Coupling -- 4. Early Attempts to Form the Left-Hand Ring -- 5. Construction of the Left-Hand Ring -- 6. Oxidative Coupling Is Enabled by an Unexpected Additive 
505 0 |a 7. Right-Hand Macrolactamization and One Final Surprise -- 8. Anticancer Screening -- 9. Conclusion -- Acknowledgments -- References -- 3. The Upside of Panic: Developing a Synthesis of Englerin A / William J. Chain -- 1. Introduction: Carbonyls and Target Selection -- 2. Putting the Pieces Together: Developing a Carbonyl-Based Synthesis of Englerin A -- 3.Completing Englerin A -- 4. Conclusions, Thoughts, and Future Directions -- Acknowledgments -- References -- 4. Total Synthesis of Anislactone A and (�)-Merrilactone A / Naim Nazef -- 1. Introduction -- 2. First-Generation Synthesis of (�)-Merrilactone A and (�)-Anislactone A -- 3. Conclusions -- 4. Merrilactone A: Second-Generation Synthesis -- 5. Conclusions -- Acknowledgments -- References -- 5. Symmetry-Driven Total Synthesis of Merrilactone A and Resolvin E2 / Daisuke Urabe -- 1.introduction -- 2. Total Synthesis of Merrilactone A -- 3. Total Synthesis of Resolvin E2 -- 4. Conclusion -- Acknowledgments -- References 
505 0 |a 6. The Circuitous Journey from Malonamides to BTPhens: Ligands for Separating Actinides from Lanthanides / Laurence M. Harwood -- 1. Introduction: Partitioning of Minor Actinides and Some Fission Products Within the Nuclear Fuel Cycle -- 2. Some Fundamental Aspects of the Chemistry of Minor Actinides -- 3. The Required Properties of the Solvent Extraction Reagents -- 4. Coextraction of Americium(III) and Europium(III): The "Easy Bit" -- 5. Selective Separation of Americium(III) from Europium(III) at High Acidity: The "Hard Bit" -- 6. The Future Prospects -- Acknowledgments -- References -- 7. Total Syntheses of Hamigeran B / Laurence Miesch -- 1. Introduction -- 2. Nicolaou's Synthesis -- 3. Clive and Wang's Syntheses -- 4. Trost's Synthesis -- 5. Taber's Synthesis -- 6. Our Approaches -- 7. Stoltz's Synthesis -- 8. Lau's Synthesis -- 9. Conclusion -- Acknowledgments -- References -- 8. Exploring Prins Strategies for the Synthesis of Okilactomycin / Karl A. Scheidt -- 1. Introduction 
505 0 |a 2. Our Synthetic Approach -- 3. Conclusions -- Acknowledgments -- References -- 9. Taking Risks in Complex Synthesis Design / Jeffrey D. Mighion -- 1. Introduction -- 2. Some Examples of Architectural Self-constructions and the Power of Proximity in Complex Synthesis Design -- 3. Targeting the Truly Fragile: Danishefsky's Synthesis of Disodium Prephenate -- 4.A Lesson on How to Produce a "Bent Benzene": Baran's Synthesis of Haouamine -- 5. The Allylic Diazene Rearrangement in a Sophisticated Molecular Context: Schreiber's Synthesis of Dynemicin A-Like Compounds -- 6. Harnessing the Reactivity of Peroxyl Radicals: Corey's Remarkable Synthesis of Prostaglandin Endoperoxide PGG2 Methyl Ester -- 7. Concluding Remarks -- Acknowledgments -- References -- 10. Stereoselective Addition of Halogen to Conjugated Enynes and Its Application in the Total Syntnesis of ( -- )-Kumausallene / Weiping Tang -- 1. Introduction -- 2. Halogen-Promoted 1,4-Addition to 1,3-Enynes 
505 0 |a 3. Retrosynthetic Analysis of ( -- )-Kumausallene -- 4. Stereoselective Synthesis of ( -- )-Kumausallene -- 5. Conclusion -- References -- 11. Total Synthesis of Aspergillide C / Stephen P. Waters -- 1. Introduction: Identification of the Aspergillides as Synthetic Targets -- 2. Synthetic Studies on Aspergillide C -- 3. Waters' Synthesis of (+)-Aspergillide C -- 4. Conclusions and Future Directions. 
650 0 |a Organic compounds  |x Synthesis. 
650 6 |a Compos�es organiques  |x Synth�ese.  |0 (CaQQLa)201-0020323 
650 7 |a SCIENCE  |x Chemistry  |x Organic.  |2 bisacsh 
650 7 |a Organic compounds  |x Synthesis  |2 fast  |0 (OCoLC)fst01047668 
700 1 |a Harmata, Michael,  |d 1959-  |e editor. 
776 0 8 |i Print version:  |t Strategies and tactics in organic synthesis. Volume 9  |z 9780080993621  |w (OCoLC)850337100 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780080993621  |z Texto completo 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/bookseries/18746004/9  |z Texto completo