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Prostaglandins and thromboxanes /
Prostaglandins and Thromboxanes explores the two members of the prostanoid class of fatty acid. This book attempts to thoroughly discuss the topic after collecting enough information through research in physical and biological sciences. As the title suggests, the book revolves around prostaglandins...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Butterworth Scientific,
1982.
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| Colección: | Butterworth's monographs in chemistry.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Prostaglandins and Thromboxanes; Copyright Page; Preface; Contributors; Table of Contents; CHAPTER 1. History, nomenclature and potential uses of prostaglandins and thromboxanes in the clinic; History; Structures and nomenclature of prostaglandins; Occurrence; Biosynthesis and metabolism; Potential clinical uses; CHAPTER 2. Biosynthesis and metabolism of prostaglandins and thromboxanes; Introduction; Prostaglandin biosynthesis; Prostaglandin metabolism (see Figure 2.7); References; CHAPTER 3. Pharmacology of natural prostaglandins and analogues; Introduction
- Mechanism of action of prostaglandins and thromboxanesTherapeutic applications of prostaglandins; Further reading; References; CHAPTER 4. Synthesis of prostaglandins from polycyclic molecules; Introduction; Harvard synthesis; Glaxo synthesis; References; CHAPTER 5. Synthesis of prostaglandins involving conjugate addition to cyclopentenones; Introduction; Conjugate addition to 2,4-disubstituted cyclopentenones (see Figure 5.2); Prostaglandin synthesis by conjugate addition and enolate trapping; References
- CHAPTER 6. Chemical interconversions of prostaglandins: synthesis of prostaglandins G2, H2, and I2Introduction; Chemical interconversions of prostaglandins D, E and F; Chemical interconversions of prostaglandins A, B, C and E; Reduction of prostaglandins of the 2-series to prostaglandins of the 1-series; Synthesis of prostaglandins G2and H2; Synthesis of prostaglandin I2; References; CHAPTER 7. Synthesis of thromboxanes; Introduction; Synthesis of TXB2 from prostaglandins and prostaglandin precursors; Synthesis from carbohydrates; References
- CHAPTER 8. Synthesis and biological activity of prostaglandin analogues bearing modified side chainsIntroduction; Alkyl substituted analogues; Dehydro analogues; Aryloxy substituted analogues; Heteroatom substituted analogues; C-1 Modified analogues; Hybrid analogues; References; CHAPTER 9. Synthesis and biological activity of prostaglandin analogues with modified ring systems; Introduction; Incorporation of additional ring substituents; Deoxyprostaglandins; Additional fused rings; Replacement of the cyclopentane ring; Prostaglandin endoperoxide analogues; Prostaglandin h analogues