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Hormones and Breast Cancer /
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. Under the capable and qualified editorial le...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
North Hollywood, CA :
Elsevier Science & Technology,
2013.
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| Edición: | First edition. |
| Colección: | Vitamins and hormones ;
v. 93. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Hormones and Breast Cancer; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Estrogen-Mediated Mechanisms to Control the Growth and Apoptosis of Breast Cancer Cells: A Translational Res ...; 1. Introduction; 2. Clinical Presentation of Breast Cancer; 3. Targeted Therapy; 3.1. Foundations of chemical therapy; 3.2. The first chemical therapy to treat cancer; 3.3. Nonsteroidal antiestrogens; 4. Transition to Tamoxifen; 5. Selective Estrogen Receptor Modulation; 6. Acquired Drug Resistance and the Surprise of SERMs
- 7. Estrogen-Induced Apoptosis: Back to the Beginning8. The Legacy of Tamoxifen; Acknowledgments; References; Chapter Two: The Epidemiology and Molecular Mechanisms Linking Obesity, Diabetes, and Cancer; 1. Introduction; 2. Type 2 Diabetes and Breast Cancer; 2.1. Epidemiology; 2.1.1. Type 2 diabetes and cancer; 2.1.2. Hyperinsulinemia and breast cancer; 2.2. Insulin and insulin receptor signaling in cancer; 2.2.1. The dual role of insulin; 2.2.2. Insulin as a metabolic regulator; 2.2.3. Insulin as a mitogen; 2.2.4. IR isoforms, hybrids, and cancer
- 2.2.5. Insulin resistance, hyperinsulinemia, and breast cancer2.3. IGF signaling and breast cancer; 3. The Role of Cholesterol in Cancer Growth; 3.1. Epidemiological studies linking cholesterol and cancer; 3.1.1. Breast cancer; 3.1.2. Prostate cancer; 3.2. Molecular mechanisms linking cholesterol to cancer growth; 3.2.1. Cholesterol and breast cancer; 3.2.2. Cholesterol and prostate cancer; 3.2.3. Cholesterol in other tumor types; 3.3. Cholesterol and statins; 4. Obesity, Estrogen, and Breast Cancer; 4.1. Obesity and circulating estrogens; 4.2. Obesity and breast aromatase activity
- 4.3. Estrogen receptor and breast cancer in obesity and type 2 diabetes4.3.1. Estrogen receptor signaling; 4.3.2. ER and IGF-1R cross talk in breast cancer; 4.3.3. ER and IR signaling in hormone refractory breast cancers; 5. Current Medications for Type 2 Diabetes: Relationship to Breast Cancer; 5.1. Recombinant insulin and insulin analogs; 5.2. Insulin secretagogues; 5.3. Insulin sensitizers (biguanides and thiazolidinediones); 6. Conclusions and Future Directions; References; Chapter Three: Sex Hormone Receptors in Breast Cancer; 1. Introduction; 2. Historical Perspective