Computational toxicology : methods and applications for risk assessment /

Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who h...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Fowler, Bruce A.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press, �2013.
Temas:
Toxicology > Data processing.
Drugs > Side effects.
Toxicology > methods
Computer Simulation
Drug-Related Side Effects and Adverse Reactions
Environmental Pollutants > toxicity
Risk Assessment > methods
Toxicologie > Informatique.
Simulation par ordinateur.
M�edicaments > Effets secondaires.
simulation.
MEDICAL > Toxicology.
Drugs > Side effects
Toxicology > Data processing
Internet Resources.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • 1. Introduction / Bruce A. Fowler
  • 2. Quantitative structure-activity relationship (QSAR) models, physiologically based pharmacokinetic (PBPK) models, biologically based dose response (BBDR) and toxicity pathways / Patricia Ruiz [and three others]
  • 3. Multiple chemical exposures and risk assessment / John C. Lipscomb, Nikki Maples-Reynolds, and Moiz Mumtaz
  • 4. Modeling of sensitive subpopulations and interindividual variability in pharmacokinetics for health risk assessments / Kannan Krishnan [and three others]
  • 5. Integrated systems biology approaches to predicting drug-induced liver toxicity / Kalyanasundaram Subramanian
  • 6. Computational translation and integration of test data to meet risk assessment goals / Luis G. Valerio Jr.
  • 7. Computational translation of nonmammalian species data to mammalian species to meet REACH and next generation risk assessment needs / Edward J. Perkins and Natalia Garcia-Reyero
  • 8. Interpretation of human biological monitoring data using a newly developed generic physiological-based toxicokinetic model / Frans Jongeneelen, Wil Ten Berge, and Peter J. Boogaard
  • 9. Uses of publicly available data in risk assessment / Isaac Warren and Sorina Eftim
  • 10. Computational toxicology experience and applications for risk assessment in the pharmaceutical industry / Nigel Greene and Mark Gosink
  • 11. Omics biomarkers in risk assessment / Hong Fang [and seven others]
  • 12. Translation of computational model results for risk decisions / William Mendez and Bruce A. Fowler
  • 13. Future directions for computational toxicology for risk assessment / Bruce A. Fowler.

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