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Advances in immunology Volume 118 /
Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecul...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Academic Press,
2013.
|
| Colección: | Advances in immunology ;
v. 118. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Advances in Immunology; Copyright; Contents; Contributors; Chapter One: Fate Determination of Mature Autoreactive B Cells; 1. Introduction; 2. Formation of the Naive B Cell Repertoire; 3. B Cell Activation; 4. The Cellular Composition of GC; 5. The GC Response; 6. Regulating Autoreactivity Within the GC; 7. Cellular Mediators of GC Selection; 8. Regulation of Plasma Cells; 9. Conclusion; References; Chapter Two: Epigenetic Control of Cytokine Gene Expression: Regulation of the TNF/LT Locus and T Helper Cell Differentiation
- 1. The Components of Epigenetic Transcriptional Regulation1.1. Histone modifications; 1.1.1. Covalent modifications; 1.1.2. Histone modifying enzymes and associated factors; 1.1.2.1. Histone acetyltransferases; 1.1.2.2. Histone deacetylases; 1.1.2.3. Histone methyltransferases and demethylases; 1.1.2.4. Histone serine kinases; 1.1.2.5. Histone ubiquitylation; 1.2. DNA methylation; 1.3. Higher-order chromatin interactions; 2. Cytokine Gene Regulation; 2.1. Innate immunity: The TNF/LT locus; 2.1.1. DNA methylation at the TNF/LT locus
- 2.1.2. The role of intrachromosomal interactions at the TNF/LT locus2.2. CD4+ T cell differentiation: The IFNG locus, Th2 locus, and IL17A/IL17F locus; 2.2.1. The IFNG locus; 2.2.2. The Th2 cytokine locus: IL4, IL5, and IL13; 2.2.2.1. Histone modifications; 2.2.2.2. DNA methylation; 2.2.2.3. Higher-order chromatin interactions; 2.2.3. The IL17A/IL17F locus; 2.3. Other loci; 3. Perspectives and Future Directions; Acknowledgments; References; Chapter Three: Autoimmunity in Rheumatoid Arthritis: Citrulline Immunity and Beyond; 1. Introduction
- 2. Present State of the Art Concerning Genes, Environment, and Anticitrulline Immunity in RA3. Unresolved Issues Concerning the Specificity and Genetic Basis of Autoimmune Reactions in RA: Focus on the Heterogenei ... ; 3.1. Heterogeneity of antibody reactivities; 4. Unresolved Issues Concerning the Triggering of Various Autoimmune Reactions in RA: Focus on Events Outside the Joints; 4.1. Possible mechanisms behind triggering of anticitrulline immunity; 5. Unresolved Issues Concerning the Contributions of Various Autoimmune Reactions to Symptoms of RA: Focus on Events in J ...
- 6. Conclusions Concerning Research Strategies and Efforts to Turn the Emerging Insights of Adaptive Immunity in RA into P ... References; Index; Contents of Recent Volumes; Color Plate