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PAKs, RAC/CDC42 (p21)-activated Kinases : towards the cure of cancer and other PAK-dependent diseases /
This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier,
�2013.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a PAKs, RAC/CDC42 (p21)-activated Kinases : |b towards the cure of cancer and other PAK-dependent diseases / |c edited by Hiroshi Maruta. |
| 260 | |a Amsterdam : |b Elsevier, |c �2013. | ||
| 300 | |a 1 online resource (363 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 520 | |a This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases. This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a Cover image; Title page; Table of Contents; Copyright; List of Contributors; Introduction: Pushing the Boundary Toward Clinical Application: After 35 Years, PAK Research Comes of Age; References; Acknowledgments; 1. Functional Maturation of PAKs from Unicellular to Multicellular Organisms; Abbreviations; 1.1 Introduction; 1.2 MIHCKs/PAKs and Myosin I in Unicellular Acanthamoeba and Multicellular Dictyostelium; 1.3 PAK Evolution Among Metazoans (Unicellular Versus Multicellular); 1.4 PIX in Fruit Fly Drosophila and Nematode C. elegans; 1.5 FYN/ETK-Dependent Activation of PAK1. | |
| 505 | 8 | |a 1.6 Evolution of Merlin, Nischarin, and LBK1 (PAK Inhibitors)1.7 Concluding Remarks; References; Acknowledgment; 2. Oncogenicity of PAKs and Their Substrates; Abbreviations; 2.1 Introduction; 2.2 Loss of Contact Inhibition of Growth; 2.3 Serum-Independent Growth; 2.4 Anchorage-Independent Growth; 2.5 Tumor-Induced Angiogenesis; 2.6 Metastasis/Invasion; 2.7 PAK1/PAK4-Dependent Solid Tumors; 2.8 Oncogenic Targets of PAKs; 2.9 Concluding Remarks; References; Acknowledgments; 3. Natural or Synthetic Therapeutics That Block PAKs; Abbreviations; 3.1 Introduction; 3.2 Synthetic Chemical Therapeutics. | |
| 505 | 8 | |a 3.3 Natural PAK1 Blockers3.4 PAK1 Blockers = AMPK Activators; References; Acknowledgments; 4. PAK1-3 in Infectious Diseases; 4.1 Malaria Infection; 4.2 Enterobacterial Infection; 4.3 Viral Infection; References; Acknowledgments; 5. PAK1 in Brain Diseases or Disorders; Abbreviations; 5.1 Introduction; 5.2 Tumorigenesis: NF, TSC, Retinoblastoma, and Gliomas; 5.3 Epilepsy; 5.4 Mental Retardation; 5.5 Schizophrenia; 5.6 Depression; References; 6. PAK1 in Alzheimer's and Huntington's Diseases; Abbreviations; 6.1 Alzheimer's Disease; 6.2 Huntington's Disease; References; Acknowledgments. | |
| 505 | 8 | |a 7. PAK1 Controls the Lifespa�nabbreviations; 7.1 Introduction; 7.2 Snell Dwarf Mice; 7.3 RAC-Deficient Drosophila; 7.4 PAK1 Blockers Extend the Lifespan of Tiny Animals; 7.5 Crosstalk Between PI-3 kinase-PAK1 and TOR-S6K Signaling Pathways; 7.6 The Nematode Caenorhabditis japonica as a Quicker Animal Model for Elixir Screening; 7.7 Antiaging (Methuselah) Venture; References; Acknowledgments; 8. 3D Structure and Physiological Regulation of PAKs; 8.1 The PAK Family of Protein Kinases; 8.2 Structural Mechanisms of PAK Regulation; 8.3 Alternative Mechanisms Leading to PAK Activation. | |
| 505 | 8 | |a 8.4 PAK Substrate Specificity and Downstream Signaling EventsReferences; Acknowledgments; Epilogue: "Lateral Thinking" Is the Key to a Great Leap in Biomedical Sciences; References; About the Authors. | |
| 650 | 0 | |a Protein kinases. | |
| 650 | 0 | |a Cancer. | |
| 650 | 0 | |a Proteins. | |
| 650 | 0 | |a Phosphotransferases. | |
| 650 | 0 | |a Transferases. | |
| 650 | 0 | |a Enzymes. | |
| 650 | 2 | |a Protein Serine-Threonine Kinases |0 (DNLM)D017346 | |
| 650 | 2 | |a Intracellular Signaling Peptides and Proteins |0 (DNLM)D047908 | |
| 650 | 2 | |a Proteins |0 (DNLM)D011506 | |
| 650 | 2 | |a Protein Kinases |0 (DNLM)D011494 | |
| 650 | 2 | |a Peptides |0 (DNLM)D010455 | |
| 650 | 2 | |a Amino Acids, Peptides, and Proteins | |
| 650 | 2 | |a Phosphotransferases (Alcohol Group Acceptor) |0 (DNLM)D017853 | |
| 650 | 2 | |a Chemicals and Drugs | |
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| 650 | 2 | |a Transferases |0 (DNLM)D014166 | |
| 650 | 2 | |a Enzymes |0 (DNLM)D004798 | |
| 650 | 2 | |a Enzymes and Coenzymes | |
| 650 | 2 | |a p21-Activated Kinases |0 (DNLM)D054462 | |
| 650 | 2 | |a Neoplasms |0 (DNLM)D009369 | |
| 650 | 6 | |a Prot�eines kinases. |0 (CaQQLa)201-0081630 | |
| 650 | 6 | |a Cancer. |0 (CaQQLa)201-0004683 | |
| 650 | 6 | |a S�erine/thr�eonine kinases. |0 (CaQQLa)000266831 | |
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| 650 | 6 | |a Transf�erases. |0 (CaQQLa)201-0024710 | |
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| 650 | 7 | |a protein. |2 aat |0 (CStmoGRI)aat300206575 | |
| 650 | 7 | |a enzyme. |2 aat |0 (CStmoGRI)aat300212647 | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x Cancer. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Oncology. |2 bisacsh | |
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| 650 | 7 | |a Proteins. |2 fast |0 (OCoLC)fst01079711 | |
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| 650 | 7 | |a Enzymes. |2 fast |0 (OCoLC)fst00913605 | |
| 650 | 7 | |a Cancer. |2 fast |0 (OCoLC)fst00845317 | |
| 650 | 7 | |a Protein kinases. |2 fast |0 (OCoLC)fst01079695 | |
| 655 | 4 | |a Internet Resources. | |
| 655 | 4 | |a Portraits. | |
| 700 | 1 | |a Maruta, Hiroshi. | |
| 776 | 0 | 8 | |i Print version: |a Maruta, Hiroshi. |t PAKs, RAC/CDC42 (p21)-activated Kinases : Towards the Cure of Cancer and Other PAK-dependent Diseases. |d Burlington : Elsevier Science, �2013 |z 9780124071988 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780124071988 |z Texto completo |