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The organic chemistry of drug design and drug action.
Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that rationalize drug action an...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Burlington :
Elsevier Science,
2004.
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| Edición: | 2nd ed. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Dedication; The Organic Chemistry of Drug Design and Drug Action; Copyright Page; Table of Contents; Preface to the First Edition; Preface to the Second Edition; Chapter 1. Introduction; 1.1 Medicinal Chemistry Folklore; 1.2 Discovery of New Drugs; 1.3 General References; 1.4 References; Chapter 2. Drug Discovery, Design, and Development; 2.1 Drug Discovery; 2.2 Lead Modification: Drug Design and Development; 2.3 General References; 2.4 Problems; 2.5 References; Chapter 3. Receptors; 3.1 Introduction; 3.2 Drug-Receptor Interactions; 3.3 General References; 3.4 Problems.
- 3.5 ReferencesChapter 4. Enzymes; 4.1 Enzymes as Catalysts; 4.2 Mechanisms of Enzyme Catalysis; 4.3 Coenzyme Catalysis; 4.4 Enzyme Therapy; 4.5 General References; 4.6 Problems; 4.7 References; Chapter 5. Enzyme Inhibition and Inactivation; 5.1 Why Inhibit an Enzyme?; 5.2 Drug Resistance; 5.3 Drug Synergism (Drug Combination); 5.4 Reversible Enzyme Inhibitors; 5.5 Irreversible Enzyme Inhibitors; 5.6 General References; 5.7 Problems; 5.8 References; Chapter 6. DNA-Interactive Agents; 6.1 Introduction; 6.2 DNA Structure and Properties; 6.3 Classes of Drugs That Interact with DNA.
- 6.4 Epilogue to Receptor-Interactive Agents6.5 General References; 6.6 Problems; 6.7 References; Chapter 7. Drug Metabolism; 7.1 Introduction; 7.2 Synthesis of Radioactive Compounds; 7.3 Analytical Methods in Drug Metabolism; 7.4 Pathways for Drug Deactivation and Elimination; 7.5 General References; 7.6 Problems; 7.7 References; Chapter 8. Prodrugs and Drug Delivery Systems; 8.1 Enzyme Activation of Drugs; 8.2 Mechanisms of Drug Activation; 8.3 General References; 8.4 Problems; 8.5 References; Appendix: Answers to Chapter Problems; Index.