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The organic chemistry of drug design and drug action.
Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that rationalize drug action an...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Burlington :
Elsevier Science,
2004.
|
| Edición: | 2nd ed. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a Silverman, Richard B. | |
| 245 | 1 | 4 | |a The organic chemistry of drug design and drug action. |
| 250 | |a 2nd ed. | ||
| 260 | |a Burlington : |b Elsevier Science, |c 2004. | ||
| 300 | |a 1 online resource (650 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 520 | |a Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that rationalize drug action and allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and now includes color illustrations, chapter problems, and other elements that make concepts easier to understand.* Or. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a Front Cover; Dedication; The Organic Chemistry of Drug Design and Drug Action; Copyright Page; Table of Contents; Preface to the First Edition; Preface to the Second Edition; Chapter 1. Introduction; 1.1 Medicinal Chemistry Folklore; 1.2 Discovery of New Drugs; 1.3 General References; 1.4 References; Chapter 2. Drug Discovery, Design, and Development; 2.1 Drug Discovery; 2.2 Lead Modification: Drug Design and Development; 2.3 General References; 2.4 Problems; 2.5 References; Chapter 3. Receptors; 3.1 Introduction; 3.2 Drug-Receptor Interactions; 3.3 General References; 3.4 Problems. | |
| 505 | 8 | |a 3.5 ReferencesChapter 4. Enzymes; 4.1 Enzymes as Catalysts; 4.2 Mechanisms of Enzyme Catalysis; 4.3 Coenzyme Catalysis; 4.4 Enzyme Therapy; 4.5 General References; 4.6 Problems; 4.7 References; Chapter 5. Enzyme Inhibition and Inactivation; 5.1 Why Inhibit an Enzyme?; 5.2 Drug Resistance; 5.3 Drug Synergism (Drug Combination); 5.4 Reversible Enzyme Inhibitors; 5.5 Irreversible Enzyme Inhibitors; 5.6 General References; 5.7 Problems; 5.8 References; Chapter 6. DNA-Interactive Agents; 6.1 Introduction; 6.2 DNA Structure and Properties; 6.3 Classes of Drugs That Interact with DNA. | |
| 505 | 8 | |a 6.4 Epilogue to Receptor-Interactive Agents6.5 General References; 6.6 Problems; 6.7 References; Chapter 7. Drug Metabolism; 7.1 Introduction; 7.2 Synthesis of Radioactive Compounds; 7.3 Analytical Methods in Drug Metabolism; 7.4 Pathways for Drug Deactivation and Elimination; 7.5 General References; 7.6 Problems; 7.7 References; Chapter 8. Prodrugs and Drug Delivery Systems; 8.1 Enzyme Activation of Drugs; 8.2 Mechanisms of Drug Activation; 8.3 General References; 8.4 Problems; 8.5 References; Appendix: Answers to Chapter Problems; Index. | |
| 546 | |a English. | ||
| 504 | |a Includes bibliographical references and index. | ||
| 650 | 0 | |a Pharmaceutical chemistry. | |
| 650 | 0 | |a Bioorganic chemistry. | |
| 650 | 0 | |a Molecular pharmacology. | |
| 650 | 0 | |a Drugs |x Design. | |
| 650 | 0 | |a Chemistry, Organic. | |
| 650 | 0 | |a Pharmacokinetics. | |
| 650 | 1 | 2 | |a Chemistry, Pharmaceutical |0 (DNLM)D002626 |
| 650 | 2 | 2 | |a Chemistry, Organic |0 (DNLM)D002625 |
| 650 | 2 | 2 | |a Drug Design |0 (DNLM)D015195 |
| 650 | 2 | 2 | |a Pharmacokinetics |0 (DNLM)D010599 |
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| 650 | 6 | |a Chimie bio-organique. |0 (CaQQLa)201-0150662 | |
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| 650 | 6 | |a Chimie organique. |0 (CaQQLa)201-0004956 | |
| 650 | 6 | |a Pharmacocin�etique. |0 (CaQQLa)201-0070307 | |
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| 650 | 7 | |a Drugs |x Design |2 fast |0 (OCoLC)fst00898790 | |
| 650 | 7 | |a Molecular pharmacology |2 fast |0 (OCoLC)fst01024822 | |
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| 776 | 0 | 8 | |i Print version: |a Silverman, Richard B. |t Organic Chemistry of Drug Design and Drug Action. |d Burlington : Elsevier Science, �2004 |z 9780126437324 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780126437324 |z Texto completo |