Eukaryotic RNases and their partners in RNA degradation and biogenesis Part B /

This special volume of The Enzymes is targeted towards researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses Eukaryotic RNases and their partners in RNA degradation and biogenesis. Key features: * Contributions from leading authorities * In...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Chanfreau, Guillaume, Tamanoi, Fuyuhiko
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego : Academic Press, 2012.
Edición:1st ed.
Colección:Enzymes ; v. 32.
Temas:
Enzymes.
Eukaryotic cells.
RNA.
RNA Stability
Biogenesis.
Eukaryotic Cells
Enzymes
RNA
Cellules eucaryotes.
ARN.
enzyme.
Eukaryotic cells
Acceso en línea:Texto completo

MARC

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245 0 0 |a Eukaryotic RNases and their partners in RNA degradation and biogenesis  |n Part B /  |c edited by Guillaume F. Chanfreau, Fuyuhiko Tamanoi. 
250 |a 1st ed. 
260 |a San Diego :  |b Academic Press,  |c 2012. 
300 |a 1 online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 0 |a Enzymes,  |x 1874-6047 ;  |v v. 32 
504 |a Includes bibliographical references and indexes. 
520 |a This special volume of The Enzymes is targeted towards researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses Eukaryotic RNases and their partners in RNA degradation and biogenesis. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field. 
505 0 |a Front Cover; Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part A; Copyright; Contents; Preface; Chapter One: Biochemistry and Function of RNA Exosomes; 1. Introduction; 2. Cellular Functions of the Exosome; 2.1. Nuclear substrates; 2.2. RNA QC by the exosome; 2.3. mRNA turnover; 2.4. Regulation of chromatin activity by the exosome; 3. Composition of Exosomes and Their Related Complexes; 3.1. Ancestors of the eukaryotic exosome; 3.2. The eukaryotic exosome; 3.3. Enzymatic activities of the eukaryotic exosome; 3.3.1. The endo/exonuclease Dis3 
505 8 |a 3.3.2. The exonuclease Rrp63.3.3. Activities of Exo10 and Exo11; 4. Exosome Cofactors; 4.1. Mtr4: A central helicase in nuclear RNA metabolism; 4.2. The Saccharomyces cerevisiae TRAMP complex and its human counterpart; 4.3. Rrp47p/C1D; 4.4. Mpp6; 4.5. Nrd1p and Nab3p; 4.6. The NEXT complex; 4.7. The SKI complex; 5. Concluding Remarks; Acknowledgments; References; Chapter Two: Plant Exosomes and Cofactors; 1. Introduction; 2. Composition of the Plant Exosome Core Complex; 2.1. Plant exosome subunits are often encoded by duplicated genes; 2.2. The exosome core complex of A. thaliana 
505 8 |a 2.3. Arabidopsis CSL4 is dispensable for the stability of the core complex2.4. Functional specialization of exosome core subunits?; 2.4.1. Take home message 1; 3. Exosome-Related Activities and Cofactors in Plants; 3.1. Plants may have retained a catalytically active core complex; 3.2. Three RRP6-like proteins in different intracellular compartments; 3.3. The SKI complex is conserved in plants; 3.4. The Arabidopsis MTR4 homologue is a nucleolar protein; 3.4.1. Take home message 2; 4. Impact of Exosome-Mediated Degradation in Plants 
505 8 |a 4.1. Polyadenylated substrates of the exosome have been identified4.2. A high level of redundancy among plant RNA degradation pathways; 5. Final Remarks; References; Chapter Three: Structure and Activities of the Eukaryotic RNA Exosome; 1. Introduction; 2. Global Architecture of the Eukaryotic Exosome Core; 3. RNase PH-Like Domains Comprise a PH-Like Ring in Eukaryotic Exosomes; 4. S1 and KH Domains Cap the PH-Like Ring; 5. Rrp44, a Hydrolytic Endoribonuclease and Processive Exoribonuclease; 6. Rrp44 and the 10-Component Exosome 
505 8 |a 7. Rrp6, a Eukaryotic Exosome Subunit with Distributive Hydrolytic Activities8. Rrp44, Rrp6, and the 11-Component Nuclear Exosome; 9. Conclusions; Acknowledgments; References; Chapter Four: TRAMP Stimulation of Exosome; 1. TRAMP Is a Cofactor of Nuclear Exosome; 2. RNA Substrate Repertoire of TRAMP; 2.1. Quality control of ribosomes and the role of TRAMP on rDNA loci; 2.2. Surveillance of stable ncRNAs; 2.3. Turnover of unstable noncoding RNAs; 3. TRAMP Biochemistry and Structure; 3.1. Structure of the TRAMP complex; 3.2. RNA-binding properties of TRAMP subunits 
650 0 |a Enzymes. 
650 0 |a Eukaryotic cells. 
650 0 |a RNA. 
650 2 |a RNA Stability  |0 (DNLM)D020871 
650 2 |a Biogenesis. 
650 2 |a Eukaryotic Cells  |0 (DNLM)D005057 
650 2 |a Enzymes  |0 (DNLM)D004798 
650 2 |a RNA  |0 (DNLM)D012313 
650 6 |a Enzymes.  |0 (CaQQLa)201-0002557 
650 6 |a Cellules eucaryotes.  |0 (CaQQLa)201-0041437 
650 6 |a ARN.  |0 (CaQQLa)201-0024711 
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650 7 |a Eukaryotic cells  |2 fast  |0 (OCoLC)fst00916456 
650 7 |a RNA  |2 fast  |0 (OCoLC)fst01086244 
700 1 |a Chanfreau, Guillaume. 
700 1 |a Tamanoi, Fuyuhiko. 
830 0 |a Enzymes ;  |v v. 32. 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780124047419  |z Texto completo 

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