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Annual reports in medicinal chemistry. Volume 47 /
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Timely and critical reviews of imp...
| Clasificación: | Libro Electrónico |
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| Autor Corporativo: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Oxford :
Academic,
2012.
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| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
MARC
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| 245 | 0 | 0 | |a Annual reports in medicinal chemistry. |n Volume 47 / |c sponsored by the Division of Medicinal Chemistry of the American Chemical Society ; edited by Manoj C. Desai. |
| 260 | |a Oxford : |b Academic, |c 2012. | ||
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| 520 | |a Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Timely and critical reviews of important topics in medicinal chemistry. | ||
| 505 | 0 | |6 880-01 |a Personal essays. Reflections on medicinal chemistry at Merck, West Point / Paul S. Anderson -- My path in seeking new medicines / Peter R. Bernstein -- Tales of drug discovery / M. Ross Johnson -- pt. 1. Central nervous system diseases. Recent developments in targeting neuroinflammationn in disease / Allen T. Hopper [and others] -- Secretase inhibitors and modulators as a disease-modifying approach against Alzheimer's Disease -- mGluR2 activators and mGluR5 blockers advancing in the clinic for major CNS disorders / Sylvain C�elanire [and others] -- NMDA antagonists of GluN2B subtype and modulators of GluN2A, GluN2C, and GluN2D suybtypes -- recent results and developments / Kamalesh B. Ruppa, Dalton King, and Richard E. Olson -- Recent advances in the developmentof PET and SPECT tracers for brain imaging / Lei Zhang and Anabella Villalobos -- pt. 2. Cardiovascular and metabolic diseases. Case history : Eliquis (Apixaban), a potent and selective inhibitor of coagulation factor Xa for the prevention and treatment of thrombotic diseases / Donald M.p. Pinto [and others] -- AMPK activation in health and disease / Iyassu K. Sebhat and Robert W. Myers -- Type-2 diabetes and associated comorbidities as an inflammatory syndrome / Juan C. Jaen, Jay P. Powers, and Tim Sullivan -- Beyond PPARs and metformin : new insulin sensitizers for the treatment of type 2 diabetes / Philip A. Carpino and David Hepworth -- pt. 3. Inflammation pulmonary GI. Recent advances in the discovery and development of sphingosine-1-phosphate-1 receptor agonists / Alaric J. Dyckman -- Bifunctional compounds for the treatment of COPD / Gary Phillips and Michael Salmon -- Inflammatory targets for the treatment of atherosclerosis / Robert O. Hughes, Alessandra Bartolozzi, and Hidenori Takahashi. | |
| 650 | 0 | |a Pharmaceutical chemistry |v Periodicals. | |
| 650 | 0 | |a Clinical chemistry. | |
| 650 | 0 | |a Pharmaceutical chemistry. | |
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| 700 | 1 | |a Desai, Manoj C. | |
| 710 | 2 | |a American Chemical Society. |b Division of Medicinal Chemistry. | |
| 776 | 0 | 8 | |i Print version: |t Annual reports in medicinal chemistry. Volume 47. |d Oxford : Academic, 2012 |z 9780123964922 |w (OCoLC)806198309 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780123964922 |z Texto completo |
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| 880 | 0 | |6 505-01/(S |a pt. 4. Oncology. Nanotechnology therapeutics in oncology--recent developments and future outlook / Paul F. Richardson -- Small-molecule antagonists of Bcl-2 family proteins / Sean P. Brown and Joshua P. Taygerly -- Notch pathway modulators as anticancer chemotherapeutics / Vibhavari Sail and M. Kyle Hadden -- Anaplastic lymphoma kinase inhibitors for the treatment of ALK-positive cancers / Kazutomo Kinoshita, Nobuhiro Oikawa, and Takuo Tsukuda -- pt. 5. Infectious diseases. Recent advances in the discovery of dengue virus inhibitors / Jeremy Green [and others] -- Nonfluoroquinolone-based inhibitors of mycobacterial type II topoisomerase as potential therapeutic agents for TB / Pravin S. Shirude and Shahul Hameed -- HCV inhibition mediated through the nonstructural protein 5A (NS5A) replication complex / Robert Hamatake, Andrew Maynard, and Wieslaw M. Kazmierski -- pt. 6. Topics in biology. Antibody-drug conjugates for targeted cancer therapy / Victor S. Goldmacher [and others] -- 3D cell cultures : mimicking in vivo tissues for improved predictability in drug discovery / Indira Padmalayam and Mark J. Suto -- Virally encoded G Protein-coupled receptors : overlooked therapeutic opportunities/ Nuska Tschammer -- Recent advances in Wnt/β-catenin pathway small-molecule inhibitors / Daniel D. Hollsworth and Stefan Krauss -- pt. 7 Topics in drug design and discovery. Targeted covalent enzyme inhibitors / Mark C. Noe and Adam M. Gilbert -- Drug design strategies for GPCR allosteric modulators / P. Jeffrey Conn, Scott D. Kuduk, and Dario Doller -- Progress in the development of non-ATP-competitive protein kinase inhibitors for oncology / Campbell McInnes -- pt. 8. Trends. New chemical entities entering phase III trials in 2011 / Gregory T. Notte -- To market, to market--2011 / Joanne Bronson [and others]. | |