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Toxicology and Human Environments /
Annotation
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Elsevier/Academic Press,
2012.
|
| Edición: | First edition. |
| Colección: | Progress in molecular biology and translational science ;
v. 112. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Toxicology and Human Environments; Copyright; Contents; Contributors; Preface; Chapter 1: Human Environments: Definition, Scope, and the Role of Toxicology; 1. Introduction; 1.1. Description and classification of human environments; 1.2. Natural ecosystems; 1.3. Agroecosystems; 1.4. Occupational (work) environments; 1.5. Domestic and urban environments; 1.6. Military deployment environments; 1.7. Superfund and other waste disposal sites; 1.8. Terminology; 2. Toxicant Transport Between and Within Human Environments; 3. Bioprocessing of Environmental Toxicants; 4. Interactions
- 5. Risk Assessment, Risk Management, and Risk Communication6. New Approaches to the Toxicology of Human Environments; References; Chapter 2: Estimating Human Exposure: Improving Accuracy with Chemical Markers; 1. Introduction; 2. OSHA; 3. EPA; References; Chapter 3: Metabolism of Xenobiotics of Human Environments; 1. Metabolism of Xenobiotics; 2. Metabolic Reactions; 2.1. Kinetics; 2.2. Reaction types; 3. Phase I Enzymes; 3.1. Cytochrome P450 monooxygenases; 3.2. Flavin-containing monooxygenases; 3.3. Other phase I enzymes; 3.3.1. Epoxide hydrolases; 3.3.2. Prostaglandin synthetase
- 7. Variations in Total Rate and Extent of Metabolism7.1. Physicochemical factors; 7.1.1. Electrophilicity and nucleophilicity; 7.1.2. Lipophilicity; 7.1.3. Polarity; 7.1.4. Protein binding; 7.1.5. Size; 7.1.6. Steric hindrance; 7.1.7. Esters; 7.1.8. Halogenation; 7.2. Endogenous factors; 7.2.1. Age; 7.2.2. Sex; 7.2.3. Species; 7.2.4. Pathology; 7.2.5. Genetics; 7.3. Exogenous factors; 7.3.1. Dose; 7.3.2. Nutrition; 7.3.3. Route of administration; 8. Summary; References; Chapter 4: Toxic Endpoints in the Study of Human Exposure to Environmental Chemicals; 1. Introduction to Toxic Endpoints
- 2. Toxicity Testing2.1. In vivo testing; 2.2. In vitro testing; 3. Carcinogenesis; 4. Hepatotoxicity; 5. Renal Toxicity; 6. Neurotoxicity; 6.1. Neurotoxic endpoints; 6.2. Environmental neurotoxicants; 7. Reproductive Toxicity; 8. Endocrine Toxicity; 9. Immunotoxicity: Respiratory; 9.1. The immune system and immunotoxic endpoints; 9.2. Immunotoxicants; 10. Concluding Remarks; References; Chapter 5: Pesticide Regulations: Exposure-Dose Modeling from FIFRA to FQPA; 1. Introduction; 2. FIFRA; 2.1. USDA; 2.2. USEPA; 2.3. Exposure to pesticide residues in food: tolerance assessment system