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Gap junctions in the brain : physiological and pathological roles /
Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
[Place of publication not identified] :
Academic Press,
2012.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Gap junctions in the brain : |b physiological and pathological roles / |c Ekrem Dere, editor. |
| 260 | |a [Place of publication not identified] : |b Academic Press, |c 2012. | ||
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| 520 | |a Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. In addition, the book also discusses human disease conditions associated with mutations in single gap junction connexion genes, making it applicable to clinicians doing translational research. Finally, it includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants. Serves as the most current and comprehensive reference available covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. Chapters summarize knowledge of the basic physiology of gap junctions in the brain, as well as of human disease conditions associated with mutations in single gap junction connexin genes. Includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants. | ||
| 588 | 0 | |a Title information from publisher's Web site; (ScienceDirect; viewed on Aug. 17, 2012). | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Front Cover; Gap Junctions in the Brain: Physiological and Pathological Roles; Copyright; Contents; About the Editor; List of Contributors; Part I -- The Physiology of Gap Junctions in the Brain; Chapter 1 -- Gap Junctions in the Brain; INTRODUCTION; STRUCTURAL ASPECTS OF GAP JUNCTIONS; TYPES OF GAP JUNCTION; CELLULAR AND BRAIN REGIONAL EXPRESSION PATTERNS OF SPECIFIC CONNEXINS; GAP JUNCTION PHARMACOLOGY; SYNCHRONIZATION AND RHYTHMIC OSCILLATION OF NEURAL ACTIVITY; GAP JUNCTION-RELATED HUMAN DISEASES; CONCLUSION; Acknowledgments; References | |
| 505 | 8 | |a Chapter2 -- Physiology and Function of Glial Gap Junctions in the HippocampusTHE CONNEXIN GENE FAMILY; INTERCELLULAR COMMUNICATION MEDIATED BY CONNEXINS; HEMICHANNEL FUNCTIONS OF CONNEXINS; NON-CHANNEL FUNCTIONS OF CONNEXINS; EXPRESSION PATTERN OF GLIAL CONNEXINS IN THE HIPPOCAMPUS: MOLECULAR, SUBCELLULAR AND CELLULAR HETEROGENEITY; HETEROCELLULAR COUPLING AND PANGLIAL COUPLING COMPARTMENTS; FUNCTIONS OF GLIAL GAP JUNCTIONS: CONTROLLING NEUROGENESIS AND NEURONAL ACTIVITY; Acknowledgments; References; Part II -- Gap Junctions between Astrocytes, Neurons, and Glia-Neuron Interactions | |
| 505 | 8 | |a Chapter 3 -- Pathophysiology of Gap Junctions in the BrainINTRODUCTION; GAP JUNCTIONS: NOMENCLATURE AND GENERAL PROPERTIES; GAP JUNCTION COUPLING IN THE BRAIN; CELL-SPECIFIC EXPRESSION OF CONNEXINS IN BRAIN TISSUES; MODULATION AND REGULATION OF ELECTRICAL SYNAPSES; NEUROTRANSMITTER MODULATION AND CONNEXIN PHOSPHORYLATION; GAP JUNCTION-RELATED NEUROLOGICAL DISEASES; GAP JUNCTIONS AND BEHAVIOR; PHARMACOLOGY OF GAP JUNCTIONS; CONCLUSION; References; Chapter 4 -- Astroglial Calcium Signaling and Calcium Waves; INTRODUCTION; GLIAL CALCIUM EXCITABILITY; ASTROGLIA: HOMEOSTATIC CELLS OF THE BRAIN | |
| 505 | 8 | |a CALCIUM SIGNALING IN ASTROCYTESASTROGLIAL CALCIUM WAVES; CONCLUSION; Acknowledgments; References; Chapter 5 -- Distribution and Function of Gap Junction Coupling in Cortical GABAergic Neurons; NEURONAL GAP JUNCTIONS AND CONNEXINS; A PREMISE ON INFERIOR OLIVE EXCITATORY NEURONS: A PRIVILEGED SITE IN THE STUDY OF NEURONAL GAP JUNCTIONS IN MAMMALS; CONNEXIN36, GAP JUNCTIONS AND ELECTRICAL COUPLING IN NEOCORTICAL GABAERGIC NEURONS; CONNEXIN36, GAP JUNCTIONS AND ELECTRICAL COUPLING IN HIPPOCAMPAL GABAERGIC INTERNEURONS | |
| 505 | 8 | |a FUNCTIONAL PROPERTIES OF CONNEXIN36 AND CONNEXIN36-BASED GAP JUNCTIONS AND THEIR ROLE IN GABAERGIC INTERNEURONAL NETWORKSReferences; Part III -- The Role of Gap Junctions in Brain Development; Chapter 6 -- Functions of Gap Junctions in the Developing Neocortex; INTRODUCTION; GAP JUNCTIONS, CONNEXONS, CONNEXINS AND THEIR DISTRIBUTION IN NEOCORTICAL NEURAL CELL TYPES; ROLE OF GAP JUNCTIONS IN THE VENTRICULAR ZONE AND DURING MIGRATION OF NEURONS; ROLE OF GAP JUNCTIONS IN THE SUBPLATE; GAP JUNCTIONS BETWEEN NEOCORTICAL GABAERGIC INHIBITORY INTERNEURONS | |
| 650 | 0 | |a Gap junctions (Cell biology) | |
| 650 | 2 | |a Gap Junctions |0 (DNLM)D017629 | |
| 650 | 6 | |a Jonctions communicantes (Biologie cellulaire) |0 (CaQQLa)201-0221274 | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Cell Biology. |2 bisacsh | |
| 650 | 7 | |a Gap junctions (Cell biology) |2 fast |0 (OCoLC)fst00937740 | |
| 700 | 1 | |a Dere, Ekrem. | |
| 776 | 0 | 8 | |i Print version: |t Gap junctions in the brain. |d London ; Waltham, MA : Elsevier/Academic Press, 2013 |z 9780124159013 |w (OCoLC)795763195 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780124159013 |z Texto completo |