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Mechanisms of DNA Repair /
Mechanisms of DNA Repair.
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Elsevier/Academic Press,
2012.
|
| Colección: | Progress in molecular biology and translational science ;
v. 110. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
MARC
| LEADER | 00000cam a2200000Ii 4500 | ||
|---|---|---|---|
| 001 | SCIDIR_ocn802058502 | ||
| 003 | OCoLC | ||
| 005 | 20231117044736.0 | ||
| 006 | m o d | ||
| 007 | cr cnu---unuuu | ||
| 008 | 120714s2012 ne af ob 001 0 eng d | ||
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| 019 | |a 968013482 |a 969080451 | ||
| 020 | |a 9780123876669 |q (electronic bk.) | ||
| 020 | |a 0123876664 |q (electronic bk.) | ||
| 020 | |a 0123876656 | ||
| 020 | |a 9780123876652 | ||
| 020 | |z 9780123876652 | ||
| 035 | |a (OCoLC)802058502 |z (OCoLC)968013482 |z (OCoLC)969080451 | ||
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| 082 | 0 | 4 | |a 616.042 |2 22 |
| 245 | 0 | 0 | |a Mechanisms of DNA Repair / |c edited by Paul W. Doetsch. |
| 264 | 1 | |a Amsterdam ; |a Boston : |b Elsevier/Academic Press, |c 2012. | |
| 300 | |a 1 online resource (xii, 323 pages, 16 unnumbered pages of plates) : |b color illustrations. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Progress in molecular biology and translational science, |x 1877-1173 ; |v v. 110 | |
| 546 | |a Text in English. | ||
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a Front Cover; Mechanisms of DNA Repair; Copyright; Contents; Contributors; Preface; Chpater 1: Dynamics of Lesion Processing by Bacterial Nucleotide Excision Repair Proteins; I. Structural Insights of Bacterial Nucleotide Excision Repair; A. Overview of the Process; B. Dynamics of the UvrA2B2-DNA Complex; C. Kinetic Proofreading as Part of a Dynamic DNA Damage Recognition Process: Role of ATP; II. So Few DNA Repair Proteins, So Much DNA: Defining the Big Problem; A. Challenge of Repair Inside a Bacterial Cell; B. Potential Modes of Damage Site Location | |
| 505 | 8 | |a B. Base Excision RepairVIII. Conclusions; Acknowledgments; References; Chpater 3: The Functions of MutL in Mismatch Repair: The Power of Multitasking; I. Overview of DNA Mismatch Repair; A. DNA Mismatch Repair in Escherichia coli; B. Strand Discrimination in Mismatch Repair in Organisms Lacking MutH; C. The Multiple Faces of MutL; II. MutL is a Multidomain Protein; A. The ATPase Domain; B. DNA Binding; C. The Dimerization Domain; III. Architecture of the Endonuclease Domain; A. The Endonuclease Site; B. MutL is an Mn2+-Dependent Endonuclease; C. The Regulatory Zn2+-Binding Site | |
| 505 | 8 | |a C. Necessary Experimental Components to Observe Single Molecules in ActionIII. Damage Searching by UvrA2 and UvrA2B2; IV. Future Directions; A. Observing Protein Nanomachines at Work; B. Overcoming the Brownian Motion Barrier; References; Chpater 2: Transcription-Coupled DNA Repair in Prokaryotes; I. Introduction; II. Background: Genomic Heterogeneity in NER and the Discovery of TCR; III. The Role of RNA Polymerase in TCR; IV. The Role of Mfd in TCR; V. The Role of UvrA in TCR; VI. The Role of UvrB in TCR; VII. Other Examples of Transcription-Related DNA Damage Processing in Bacteria; A. NusA | |
| 505 | 8 | |a Chpater 5: Regulation of Base Excision Repair in Eukaryotes by Dynamic Localization StrategiesI. Base Excision Repair; A. Requirements and Limitations of Base Excision Repair; B. Regulation of BER: Current Concepts and Observations; C. Dynamic Localization; II. Dynamic Localization of BER Proteins; A. General Pathway; B. Requirements to Dynamically Localize; C. Examples of Dynamic Localization in Response to Genotoxic Stress; D. Insight into Dynamic Localization; III. Hypotheses on the Orchestration of Dynamic Localization; References | |
| 505 | 8 | |a D. The Endonuclease Activity of MutLIV. Regulation of the Endonuclease Activity of MutL; A. DNA Binding; B. Stimulatory Effect of the Processivity Clamp; C. Mismatch Dependency; V. Concluding Remarks; References; Chpater 4: The Fpg/Nei Family of DNA Glycosylases: Substrates, Structures, and Search for Damage; I. Introduction; II. Fpg/Nei Phylogeny; III. Fpg/Nei Structures; A. Introduction; B. Substrate Preference; C. Comparison of Structures of the Fpg/Nei Family; IV. Glycosylases Search for Lesions; V. Concluding Remarks; Acknowledgments; References | |
| 520 | |a Mechanisms of DNA Repair. | ||
| 650 | 0 | |a DNA repair. | |
| 650 | 2 | |a DNA Repair |0 (DNLM)D004260 | |
| 650 | 6 | |a ADN |x R�eparation. |0 (CaQQLa)201-0047976 | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x Genetic. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Genetics. |2 bisacsh | |
| 650 | 7 | |a DNA repair |2 fast |0 (OCoLC)fst00886599 | |
| 700 | 1 | |a Doetsch, Paul W., |e editor. | |
| 830 | 0 | |a Progress in molecular biology and translational science ; |v v. 110. |x 1877-1173 | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780123876652 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/18771173/110 |z Texto completo |