Current concepts in drug metabolism and toxicology /

This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defence pathway, Animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modelling metabo...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Hawksworth, Gabrielle M.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam ; Boston : Elsevier/Academic Press, 2012.
Edición:1st ed.
Colección:Advances in pharmacology (San Diego, Calif.) ; 63.
Temas:
Drugs > Metabolism.
Toxicology.
Drugs > Side effects.
Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations > metabolism
Toxicology
M�edicaments > M�etabolisme.
Toxicologie.
M�edicaments > Effets secondaires.
toxicology.
MEDICAL > Pharmacology.
Drugs > Side effects
Drugs > Metabolism
Medical toxicology.
Pharmacology.
Health and Wellbeing.
Acceso en línea:Texto completo
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Tabla de Contenidos:
  • Front Cover; Current Concepts Indrug Metabolismand Toxicology; Copyright; Contents; Contributors; Membrane Transporters in Drug Development; Abstract; I. Introduction; II. Key Features of Transporters; III. Transporters and the Pharmaceutical Industry; IV. Studying and Contextualizing Transporter Interactions: Application and Interpretation of Data; VI. Conclusion; Acknowledgments; Abbreviations; References; The Keap1-Nrf2 Cell Defense Pathway
  • A Promising Therapeutic Target?; Abstract; I. Introduction; II. The Keap1-Nrf2 Cell Defense Pathway
  • III. Activation of Nrf2 as a Potential Therapeutic StrategyIV. Inhibition of Nrf2 as a Potential Therapeutic Strategy; V. Conclusion; Acknowledgments; Abbreviations; References; Animal Models of Idiosyncratic Drug Reactions; Abstract; I. Introduction; II. Animal Models of Skin Rash; III. Animal Models of Liver Toxicity; IV. Animal Models of Hematological Toxicity; V. Animal Models of Generalized Hypersensitivity Reactions; VI. Animal Models of Generalized Autoimmunity; VII. Conclusion; Acknowledgments; Abbreviations; References
  • Genetic Polymorphisms Affecting Drug Metabolism: Recent Advances and Clinical AspectsAbstract; I. Introduction; II. Recent Advances in the Pharmacogenetics of Cytochromes P450; III. Recent Advances in the Pharmacogenetics of Non-P450 Metabolism; IV. Clinical Relevance of Polymorphic Metabolism
  • Some Contemporary Examples; V. Conclusion; Abbreviations; References; Arylamine N-Acetyltransferases
  • from Drug Metabolism and Pharmacogenetics to Identification of Novel Targets for Pharmacological Intervention; Abstract; I. Introduction; II. NAT Enzyme Mechanism; III. NAT Genes and Pharmacogenetics
  • IV. The Genomic Distribution and Function of NATsV. NAT Gene Expression and Regulation; VI. Development of NAT Inhibitors; VII. Conclusion; Acknowledgments; Abbreviations; References; Human Pluripotent Stem Cells for Modeling Toxicity; Abstract; I. Introduction; II. The Use of Human Stem Cells in Developmental Toxicity; III. The Use of Human Stem Cells in Cardiotoxicity; IV. The Use of Human Stem Cells in Hepatotoxicity; V. The Use of Human Stem Cells in Neurotoxicity; VI. Conclusion; Abbreviations; References; Disposition of Biologics; Abstract; I. Introduction; II. Routes of Administration
  • III. Mechanisms of Biologics Distribution and Clearance, The Importance of Active ProcessesIV. Distribution Studies with Biologics and Relevance to Toxicology Studies; V. Metabolism of Biologics; VI. Consideration of Immunogenicity
  • Changes in Disposition and Impact on Toxicology; VII. Conclusion; References; Index; Recent Volumes in the Serial

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