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Protein Prenylation. Part B /
This volume of The Enzymes features high-caliber thematic articles on the topic of glycosylphosphatidylinositol (GPI) anchoring of proteins. * Contributions from leading authorities * Informs and updates on all the latest developments in the field.
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Academic Press/Elsevier,
2011.
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| Colección: | Enzymes ;
v. 30. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Protein Prenylation, Part B; Copyright; Contents; Preface; Chapter 1: The Enzymology of CAAX Protein Prenylation; II. Introduction; III. Protein FTase; IV. Protein GGTase-I; V. Conclusions; Acknowledgments; References; Chapter 2: CAAX Processing and Yeast a-Factor Biogenesis; II. Introduction; III. The a-Factor Mating Pheromone of S. cerevisiae as an Early Prototype for Dissecting the CAAX-Processing Pathway...; A. The Study of Obscure Fungal Pheromones Led to the Discovery of Farnesylation and Carboxylmethylation as Posttranslational M
- B. Links Made by Yeast Genetic Studies Between Ras and a-Factor Open Up the CAAX-Processing FieldIV. Biogenesis Pathway of a-Factor: Genetic and Biochemical Analysis of the a-Factor Machinery; A. The Yeast Mating Pheromones a-Factor and a-Factor Represent Distinct Paradigms for Biogenesis and Export of a Signaling ...; 1. a-Factor Maturation and Secretion; 2. a-Factor Maturation and Secretion; B. C-Terminal CAAX Processing; 1. Farnesylation by the Ram1/2 FTase; 2. The Rce1p and Ste24p CAAX Endproteases Are Functionally Redundant for ""AAXing"" the a-Factor CAAX Motif
- 3. Ste14p, the Founding Member of the Isoprenylcysteine Carboxylmethyltransferase (ICMT) Family, Carries Out the Final Step inC. N-Terminal Processing of a-Factor by Ste24p and Axl1p; 1. Ste24p Mediates an Unexpected ""First Step"" in the Two-Step N-terminal Processing of a-Factor; 2. Proteolytic Processing by Axl1p; D. Export of a-Factor by the ABC Transporter Ste6p; E. Interaction of Secreted a-Factor with the a-Factor Receptor Ste3p; F. The Extremely Hydrophobic Properties of a-Factor Pose Both Challenges and Advantages for the Experimentalist...; 1. Hydrophobic Properties of a-Factor
- 2. Secreted a-Factor May Be Part of a Large Complex3. Prevalence of Prenylated Pheromones Among Fungi; V. Progeria-The Role of Prenylation and ZMPSTE24 in Progeroid Disorders; VI. A Prenylated, Secreted Molecule Involved in Drosophila Germ Cell Migration Requires a Pathway Strikingly Similar to That o; Acknowledgments; References; Chapter 3: Prenylation and Phosphorylation of Ras Superfamily Small GTPases; II. Introduction; III. Small GTPase Prenylation; IV. C-Terminal Phosphorylation of Prenylated Ras Family Small GTPases
- A. K-Ras4B Phosphorylation by PKC-Alpha Alters Its Protein:Protein Interactions with Calmodulin and Gal3 and Translocates It fB. Rap1 Phosphorylation by PKA Translocates It from Membranes and May Induce Allosteric Conformational Changes to Alter Intera; C. RalA and RalB Are Differentially Phosphorylated; V. C-Terminal Phosphorylation of Prenylated Rho Family Small GTPases; A. RhoA Phosphorylation Is Complex and Regulates Its Protein:Protein Interactions, Activation, and Effector Binding...; B. RhoB Phosphorylation Inhibits Its Function; C. RhoG-C-Terminally Phosphorylated In Vitro Only?