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Biomarkers of neurological and psychiatric disease /
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely r...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier,
2011.
|
| Colección: | International review of neurobiology ;
v. 101. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- General overview: biomarkers in neuroscience research
- Imaging brain microglial activation using positron emission tomography and translocator protein-specific radioligands
- The utility of gene expression in blood cells for diagnosing neuropsychiatric disorders
- Proteomic technologies for biomarker studies in psychiatry: advances and needs
- Converging evidence of blood-based biomarkers for schizophrenia: an update
- Abnormalities in metabolism and hypothalamic-pituitary-adrenal axis function in schizophrenia
- Immune and neuroimmune alterations in mood disorders and schizophrenia
- Behavioral and molecular biomakers in translational animal models for neuropsychiatric disorders
- Stem cell models for biomarker discovery in brain disease
- The application of multiplexed assay systems for molecular diagnostics
- Algorithm development for diagnostic biomarker assays
- Challenges of introducing new biomarker products for neuropsychiatric disorders into the market
- Toward personalized medicine in the neuropsychiatric field
- Clinical utility of serum biomarkers for major psychiatric disorders
- The future: biomarkers, biosensors, neuroinformatics, and E-neuropsychiatry
- Biomarkers of Neurological and Psychiatric Disease
- Contributors
- 1. : General Overview: Biomarkers in Neuroscience Research
- I. The Quest for Biomarkers in Neuroscience
- A. Biomarkers in Clinical Practice
- B. Biomarkers for the Development of Novel Therapeutics and in Basic Research
- II. Tools for Biomarker Discovery in Neuroscience
- III. Advancements in Biomarker Discovery in Neuroscience
- A. Mouse Models
- B. Human Data
- 1. Postmortem Brain Tissue Studies
- 2. Cerebrospinal Fluid Studies
- 3. Plasma Studies
- C. Future Directions
- IV. Considerations for Biomarker Discovery and Translation in NeuroscienceA. Disease Complexity
- B. Sample Quality and Collection
- C. Candidate Biomarker Validation
- D. Systemic Approaches and Biomarker Initiatives
- V. Outlook-The Perspective of Personalized Medicine
- 2. : Imaging brain microglial activation using positron emission tomography and translocator protein-specific radioligands
- I. Introduction
- II. Principles of PET Imaging
- III. TSPO for Assessment of Microglial Expression
- IV. Challenges Facing PET Imaging of the TSPO
- V. Disease Applications
- A. Neuroinflammatory DiseasesB. Neurodegenerative Diseases
- C. Movement Disorders
- 1. Parkinson's Disease
- 2. Huntington's Disease
- D. Stroke
- E. Neuropsychiatric Diseases
- VI. Conclusion
- 3. : The utility of gene expression in blood cells for diagnosing neuropsychiatric disorders
- I. Introduction
- II. Microarray Gene Expression Analysis
- III. Diagnostic Gene Expression Classifiers
- IV. Blood Gene Expression Studies of Neuropsychiatric Disorders
- V. MicroRNA Expression Analysis
- VI. Pharmacogenomics
- VII. Concluding Remarks
- 4. : Proteomic technologies for biomarker studies in psychiatry: Advances and NeedsI. Introduction
- II. The Social Impact of Psychiatric Disorders
- III. The Role of Proteomics in Psychiatry
- A. What Has Been Done So Far?
- IV Proteomic Studies in Psychiatry: What Methods Have Been Used to Date?
- A Sample Preparation
- B Two-Dimensional Gel Electrophoresis and Mass Spectrometry
- C Shotgun Proteomics
- 1. Label-Free MS
- 2. Stable Isotope Labeling
- 3. In Vivo Labeling
- D SELDI-TOF
- E Metabolomics
- F Multiplex Analyte Profiling Approach
- G What Is the Best Method for Proteome Characterization?
- V Underexplored Proteomic Methods in Psychiatry StudiesA Phosphoproteomics
- B SILAC
- C MALDI Imaging
- VI. The Importance of Validation Experiments in Proteomics for Biomarker Discovery in Psychiatry
- A. Validation Technologies
- 1. Selective Reaction Monitoring
- 2. ELISA
- 3. Western Blot
- 4. Functional Genomics
- 5. Tissue Microarray
- 6. Protein Arrays
- VII. Clinical Translation
- VIII. Summary
- 5. : Converging evidence of blood-based biomarkers for schizophrenia: An Update
- I. Introduction
- II. Methodology
- A. Compilation of Literature Serum/Plasma Biomarkers
- B. Compilation of In-House Serum Biomarkers.