Cargando…
Cholinergic mechanisms : from molecular biology to clinical significance /
This volume offers a comprehensive update and overview of the field of cholinergic transmission as presented by some thirty distinguished investigators who were recruited for their task from Germany, Great Britain, Canada, USA, Sweden, Israel, France and Italy. Exciting new discoveries, described in...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; New York :
Elsevier,
1996.
|
| Colección: | Progress in brain research ;
v. 109. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Cholinergic Mechanisms: from Molecular Biology to Clinical Significance; Copyrigth Page; List of Contributors; Preface; Contents; The Otto Loewi Lecture; Loewi's discovery and the XXI century; Section I: Neurobiology of Cholinergic Transmission; Chapter 1. Molecular properties and cellular distribution of cholinergic synaptic proteins; Chapter 2. Redistribution of clathrin and synaptophysin at the frog neuromuscular junction triggered by nerve stimulation: immunocytochemical studies of vesicle trafficking
- Chapter 3. Transcriptional regulation of the human choline acetyltransferase geneChapter 4. Biosynthesis and integration of acetylcholinesterase in the cholinergic synapse; Section II: Vesicular Acetylcholine Transporter; Chapter 5. The VAChT/ChAT "cholinergic gene locus": new aspects of genetic and vesicular regulation of cholinergic function; Chapter 6. Expression of the vesicular acetylcholine transporter in mammalian cells; Chapter 7. Interactions of protons with the acetylcholine transporter of synaptic vesicles; Section III: Neuronal Nicotinic Receptors
- Chapter 8. Nicotinic receptors of the vertebrate CNS: introductory remarksChapter 9. Nicotinic acetylcholine receptors on hippocampal neurons: cell compartment-specific expression and modulatory control of channel activity; Chapter 10. Structure and function of neuronal nicotinic acetylcholine receptors; Section IV: Muscarinic Receptors: 1. Structural Aspects; Chapter 11. 3-Heteroarylquinuclidin-2-ene derivatives as muscarinic antagonists: synthesis, structure-activity relationships and molecular modelling; Chapter 12. Allosteric regulation of muscarinic receptors
- Chapter 13. Molecular aspects of muscarinic receptor assembly and functionSection V: Muscarinic Receptors: 2. Mechanisms of Desensitization; Chapter 14. Regulation of muscarinic acetylcholine receptor expression and function; Chapter 15. The role of G-protein coupled receptor kinases in the regulation of muscarinic cholinergic receptors; Chapter 16. Activation, cellular redistribution and enhanced degradation of the G proteins Gq and G11 by endogenously expressed and transfected phospholipase C-coupled muscarinic ml acetylcholine receptors
- Section VI: Muscarinic Receptors: 3. Coupling to Intracellular Signalling PathwaysChapter 17. Muscarinic receptors and cell signalling; Chapter 18. Muscarinic receptor activated Ca2+ channels in non-excitable cells; Chapter 19. Muscarinic activation of phosphatidylcholine hydrolysis; Chapter 20. Participation of small GTP-binding proteins in m3 muscarinic acetylcholine receptor signalling to phospholipase D and C; Section VII: Presynaptic Modulation of Acetylcholine Release; Chapter 21. Modulation of acetylcholine release by nitric oxide