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Experimental and comparative toxicology /
Experimental and Comparative Toxicology, Volume 31 aims to explore some of the potentially important and crucial areas in experimental toxicology. The book discusses tumor promoters and genotoxic chemicals in short-term testing for carcinogenicity, as well as the significance of preneoplastic liver...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Orlando :
Academic,
1987.
|
| Colección: | Advances in veterinary science and comparative medicine ;
v. 31. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Experimental and Comparative Toxicology; Copyright Page; Table of Contents; Preface; Chapter 1. Tumor Promotors and Genotoxic Chemicals in Short-Term Testing for Carcinogenicity; I. Introduction; II Complete and ""Incomplete"" Carcinogens; III. Acute and Chronic Toxicity; IV. New Testing Strategies; V. Conclusions; References; Chapter 2. The Significance of Preneoplastic Liver Lesions in Experimental Animals; I. Introduction; II. Significance of Preneoplastic Lesions; III. Characteristics of Altered Foci; IV. Induction of Altered Foci as a Means of Detecting Carcinogens.
- v. Enhancement of Altered Foci as a Means of Identifying Neoplasm-Promoting AgentsVI. Inhibition of Altered Foci as a Means of Identifying Anticarcinogens; VII. Conclusions; References; Chapter 3. Liver Tumors in Rodents: Extrapolation to Man; I. Introduction; II. Different Kinds of Liver Tumors; III. Etiological Factors for Hepatic Neoplasia in Man and the Availability of Animal Models; IV. Mortality from Primary Liver Cancer in England and Wales; V. Factors Other Than Test Chemicals Which Influence the Risk of Hepatic Neoplasia in Laboratory Rodents.
- VI. The Significance of Enzyme-Altered Foci in the Pathogenesis of Hepatocellular NeoplasiaVII. The Prediction of Hepatocarcinogenic Risk for Man; VIII. Summary; References; Chapter 4. Neurobehavioral Toxicology: An Overview; I. Introduction; II. Neurobehavioral Toxicology: A Historical Perspective; III. Methods in Neurobehavioral Toxicology; IV. Corroborating Tests; V. Neurobehavioral Assessment of Neurotoxins: Past and Present; VI. Topics for Future Research; References; Chapter 5. Immunotoxicology; I. Introduction; II. Brief Anatomical and Physiological Considerations.
- Chapter 8. Predictive Value of Ocular Irritation TestsI. Introduction; II. Tests Presently Used; III. Are Tests Presently Used Predictive?; IV. Can We Improve the Predictivity of the Tests?; V. Can We Develop Alternative Methods to the Use of Animals?; VI. Conclusions; References; Index.