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111030s1984 maua ob 001 0 eng d |
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|a OCLCE
|b eng
|e pn
|c OCLCE
|d OCLCQ
|d OPELS
|d OCLCF
|d E7B
|d OCLCQ
|d INARC
|d UKAHL
|d VLY
|d OCL
|d OCLCO
|d OCLCA
|d OCLCQ
|d OCLCO
|d OCLCQ
|d OCLCO
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|a 755249986
|a 1029262374
|a 1162329514
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|a 9780250405473
|q (electronic bk.)
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|a 0250405474
|q (electronic bk.)
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|a 1483191826
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|a 9781483191829
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|a (OCoLC)759097604
|z (OCoLC)755249986
|z (OCoLC)1029262374
|z (OCoLC)1162329514
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|a RA1199
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|a QV 602
|b C517 1984
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|a RA1199.C48
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|a 615.9/07
|2 19
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|a Chemistry for toxicity testing /
|c edited by C.W. Jameson and Douglas B. Walters.
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|a Boston :
|b Butterworth Publishers,
|c �1984.
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|a 1 online resource (xiv, 231 pages) :
|b illustrations
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a Includes bibliographical references and index.
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|a Print version record.
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|a Front Cover; Chemistry for Toxicity Testing; Copyright Page; Dedication; Table of Contents; THE EDITORS; THE CONTRIBUTORS; PREFACE; PART I: General Chemistry Considerations; CHAPTER 1. Analytical Chemistry Requirements for Toxicity Testing of Environmental Chemicals; PROTOCOL DEVELOPMENT; CHEMICAL PROCUREMENT; CHEMICAL ANALYSIS; CONCLUSION; REFERENCES; CHAPTER 2. Structure-Activity Prediction of the Carcinogenicity of Chemicals; RATIONALE; METHODOLOGY; PRACTICAL APPLICATIONS; FUTURE DEVELOPMENTS; SUMMARY; REFERENCES; CHAPTER 3. Problems of Testing Commercial-Grade Chemicals
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|a CHEMICAL PROCUREMENTCHEMICAL ANALYSIS; PROBLEMS IN CHEMICAL ANALYSES; CONCLUSION; CHAPTER 4. Chemical/Vehicle Mixing and Analysis Problems at a Bioassay Laboratory; DOSAGE PREPARATION; PERSONNEL; SUMMARY; PART II: Dosage Mixing and Analysis; CHAPTER 5. Methods Development for Mixing Chemicals in Rodent Feed; FACTORS AFFECTING FEED BLEND HOMOGENEITY; PRELIMINARY MIXING STUDIES; HOMOGENEITY EVALUATION; EXTENDED MIXING STUDIES; DISCUSSION; CONCLUSION; CHAPTER 6. Formulations of Insoluble and Immiscible Test Agents in Liquid Vehicles for Toxicity Testing; DISCUSSION; CONCLUSION; REFERENCES
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|a CHAPTER 7. Analysis of Dosed Feed SamplesGENERAL COMMENTS CONCERNING THE CHEMICAL/FEED MIX; DEVELOPMENT OF THE ANALYTICAL METHOD; STABILITY ANALYSIS; DOSAGE ANALYSIS; CONCLUSION; REFERENCE; CHAPTER 8. Stability Determinations for Chemical/Vehicle Mixtures; ROUTES OF ADMINISTRATION; CONCLUSION; PART III: Chemical Inhalation Studies; CHAPTER 9. Inhalation Toxicology: An Overview; CHAMBER DESIGN AND OPERATION; CHARACTERISTICS OF EXPERIMENTAL ATMOSPHERES; HEALTH AND SAFETY OF EMPLOYEES; MAINTENANCE OF EXPERIMENTAL ANIMALS; EXPERIMENTAL DESIGN; ASSESSMENT OF BIOLOGIC EFFECTS; QUALITY CONTROL
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|a CHAPTER 13. Detection of Degradation Products in Inhalation Test Atmospheres and Analysis in Combustion Products ToxicologyDEGRADATION IN INHALATION TEST ATMOSPHERES; COMBUSTION PRODUCTS TOXICOLOGY; SUMMARY; REFERENCES; CHAPTER 14. Analytical Monitoring for Both Intentional and Unintentional Test Chemical Release during the Conduct of Inhalation Toxicity Studies; EQUIPMENT AND METHODS; RESULTS; CONCLUSION; PART IV: Chemistry Data Evaluation; CHAPTER 15. Data Evaluation and Management; MANAGEMENT CONCERNS; DECISION FLOWCHARTS; CONTROL CHARTS; SUMMARY; CONCLUSION; REFERENCES
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|a CHAPTER 10. Methods for Generation of Test Atmospheres; BASIC PRINCIPLES; TECHNIQUES FOR GENERATION OF VAPORS; TECHNIQUES FOR GENERATION OF AEROSOLS; SUMMARY; REFERENCES; CHAPTER 11. Monitoring Vapor Concentrations in Test Atmospheres; SAMPLE COLLECTION; SAMPLE ANALYSIS; INSTRUMENT CALIBRATION; SUMMARY; REFERENCES; CHAPTER 12. Chemical Monitoring of Aerosols in Inhalation Chambers; FORWARD SCATTER DETECTORS TDA-2DN; RAM-1; BACK SCATTER DETECTOR RAM-1; CASCADE IMPACTOR OPERATION; SUMMARY; REFERENCES
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|a Chemistry for Toxicity Testing presents the chemical requirements for external toxicity studies. This book is organized into four parts encompassing 18 chapters that discuss the basic chemistry considerations for toxicity testing program. It also describes the structure-activity prediction of the carcinogenicity of chemicals and the development of methods for mixing chemicals in rodent feed. Some of the topics covered in the book are the formulations of insoluble and immiscible test agents in liquid medium for toxicity testing; problems of testing commercial-grade chemicals; analysis of dosed.
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546 |
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|a English.
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650 |
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|a Toxicity testing.
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650 |
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|a Analytical chemistry.
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650 |
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|a Chemistry Techniques, Analytical
|x methods
|0 (DNLM)D002623Q000379
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650 |
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2 |
|a Toxicology
|x methods
|0 (DNLM)D014116Q000379
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650 |
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|a Chimie analytique.
|0 (CaQQLa)201-0008034
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650 |
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|a chemical analysis.
|2 aat
|0 (CStmoGRI)aat300081685
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650 |
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|a Analytical chemistry
|2 fast
|0 (OCoLC)fst00853459
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650 |
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7 |
|a Toxicity testing
|2 fast
|0 (OCoLC)fst01153336
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650 |
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7 |
|a Tests de toxicit�e.
|2 ram
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653 |
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|a Chemicals
|a Toxic effects
|a Analysis
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700 |
1 |
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|a Jameson, C. W.
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700 |
1 |
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|a Walters, Douglas B.
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776 |
0 |
8 |
|i Print version:
|t Chemistry for toxicity testing.
|d Boston : Butterworth Publishers, �1984
|w (DLC) 83019031
|w (OCoLC)9970985
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856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780250405473
|z Texto completo
|