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Advances in immunology Volume 110 /
Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecul...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Academic Press/Elsevier,
2011.
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| Edición: | 1st ed. |
| Colección: | Advances in immunology ;
v. 110. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Immunology; Copyright; Contents; Contributors; Chapter 1: AID Targeting in Antibody Diversity; Introduction; Features of AID-Mediated Mutation; Transcription is Necessary for AID Targeting; DNA Elements, Secondary Structure and Trans-Acting Factors in SHM and CSR; Insights From in vitro Studies: ssDNA is the Substrate for AID; The Role of Transcriptional Stalling in AID Targeting; Concluding Remarks; References; Chapter 2: The IgH Locus 3' Regulatory Region: Pulling the Strings from Behind; Introduction; IgH Loci and Regulatory Elements in Evolution
- The Unique Structure of the IgH 3� RR3'RR Activity and Chromatin Conformation During B-Cell Ontogeny; Transcription Factors Controlling the IgH 3'RR; The IgH 3'RR Orchestrates the Expression of IgH C Genes; Mechanism for IgH 3'RR-Mediated Effects: Is it All about Transcription?; Regulatory Regions in Other Complex Loci: Lessons for IgH Locus Regulation; The IgH 3'RR in Pathology; Conclusion; References; Chapter 3: Transcriptional and Epigenetic Regulation of CD4/CD8 Lineage Choice; Introduction: The CD4/CD8 Lineage Choice; Regulation of CD4/CD8 Coreceptor Expression
- Transcription Factors Regulating Cd4/Cd8 Gene Expression and Lineage Choice of DP ThymocytesOther Transcription Factors Involved in Lineage Choice; Regulation of ThPOK Gene Expression; Conclusion; Acknowledgments; References; Chapter 4: Modeling a Complex Disease: Multiple Sclerosis; Multiple Sclerosis: a Heterogeneous Disease to Model; The Original Model: EAE; T Cell Receptor Transgenic Models and Spontaneous Disease; CD8 Cells in MS and EAE; Variances of MS: IFNgamma Versus IL-17-Mediated MS; Genetic Models of Myelin Defects with Similarities to MS
- New Transgenic Oligodendrocyte Degeneration ModelsLate Neurodegenerative Phase; Perspective and Conclusion; Acknowledgments; References; Chapter 5: Autoinflammation by Endogenous DNA; Introduction; DNA Degradation in Apoptotic Cell Death; Degradation of DNA in Macrophages; Interferon-Dependent Lethal Anemia in DNase II-Deficient Embryos; Cytokine-Dependent, but Lymphocyte-Independent, Arthritis; Signal Transduction From DNA to Cytokine Production; Concluding Remarks; Acknowledgments; References; Index; Contents of Recent Volumes